gene

RAB3A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections

0Hypotheses

0Analyses

29Outgoing

15Incoming

0Experiments

0Debates

Summary

RAB3A is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, activates. Associated with ALS, Als, Ms. Connected to 30 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RAB3A
Full Name	Ras-Related Protein Rab-3A
Function	is a synaptic vesicle-associated small GTPase that plays a central role in regulating neurotransmitter release[@raba2018][@rab2020].
Subcellular Localization	synaptic vesicles and other secretory organelles, making it a key component of the presynaptic machinery. The widespread
Molecular Weight	25 kDa
Amino Acids	35 aa
Pathways	Synaptic Vesicle Exocytosis
GeneCards	RAB3A
Human Protein Atlas	RAB3A
Associated Diseases	Als
Interactions	AXON, GDI1, LRRK2, PARKINSON, PARKINSON'S DISEASE, RAB27B
KG Connections	44 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RAB3A["RAB3A"]
    Als{"Als"}
    RAB3A -->|"associated with"| Als
    Parkinson{"Parkinson"}
    RAB3A -->|"interacts with"| Parkinson
    RAB3A -->|"interacts with"| Als
    Ms{"Ms"}
    RAB3A -->|"interacts with"| Ms
    ALS{"ALS"}
    RAB3A -->|"associated with"| ALS
    Exocytosis(["Exocytosis"])
    RAB3A -->|"activates"| Exocytosis
    RAB3B["RAB3B"]
    RAB3A -->|"associated with"| RAB3B
    RAB10["RAB10"]
    RAB3A -->|"associated with"| RAB10
    RAB11B["RAB11B"]
    RAB3A -->|"associated with"| RAB11B
    RAB3C["RAB3C"]
    RAB3A -->|"associated with"| RAB3C
    RAB5A["RAB5A"]
    RAB3A -->|"associated with"| RAB5A
    RAB5["RAB5"]
    RAB3A -->|"associated with"| RAB5
    RAB4B["RAB4B"]
    RAB4B -->|"associated with"| RAB3A
    RAB27B["RAB27B"]
    RAB27B -->|"activates"| RAB3A
    RAB3C -->|"associated with"| RAB3A
    RAB5 -->|"associated with"| RAB3A
    RAB3B -->|"associated with"| RAB3A
    RAB5A -->|"associated with"| RAB3A
    RAB11B -->|"associated with"| RAB3A
    RAB10 -->|"associated with"| RAB3A
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"interacts with"| RAB3A
    SYNAPTOPHYSIN["SYNAPTOPHYSIN"]
    SYNAPTOPHYSIN -->|"interacts with"| RAB3A
    GDI1["GDI1"]
    GDI1 -->|"interacts with"| RAB3A
    RAB27B -->|"causes"| RAB3A
    style RAB3A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

Target	Relation	Type	Str
Synaptic Vesicle Exocytosis	involved_in	process	0.95
RAB27B	interacts_with	protein	0.85
ALS	associated_with	disease	0.65
Als	associated_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
AXON	activates	gene	0.60
Neuron	activates	cell_type	0.60
Raf	phosphorylates	protein	0.60
RAB3B	associated_with	gene	0.60
RAB10	associated_with	gene	0.60
RAB11B	associated_with	gene	0.60
RAB3C	associated_with	gene	0.60
RAB5A	associated_with	gene	0.60
RAB5	associated_with	gene	0.60
RAB27B	activates	gene	0.60
LRRK2	activates	gene	0.60
RAB4B	associated_with	gene	0.60
Synaptic Vesicle	causes	pathway	0.60
AND	causes	gene	0.60
Exocytosis	causes	pathway	0.60
RAB27B	causes	gene	0.60
App	associated_with	protein	0.60
PARKINSON	phosphorylates	gene	0.60
Exocytosis	activates	pathway	0.60
Fus	associated_with	protein	0.60
RAB27B	associated_with	protein	0.50
Proteins	associated_with	protein	0.50

Incoming (15)

Source	Relation	Type	Str
RAB-GDI	modulates	protein	0.85
RAB27B	activates	gene	0.60
RAB3C	associated_with	gene	0.60
RAB5	associated_with	gene	0.60
RAB3B	associated_with	gene	0.60
RAB5A	associated_with	gene	0.60
RAB11B	associated_with	gene	0.60
RAB10	associated_with	gene	0.60
SYNAPTOPHYSIN	interacts_with	gene	0.60
GDI1	interacts_with	gene	0.60
RAB27B	causes	gene	0.60
RAB27B	associated_with	entity	0.60
RAB27B	expressed_in	entity	0.60
RAB4B	associated_with	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAB3A in their description or question text

No additional research found