protein

RAB12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

1Hypotheses

1Analyses

6Outgoing

7Incoming

0Experiments

1Debates

Summary

Page for RAB12 Protein

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🔬 Protein Info

Gene Symbol	RAB12
Full Name	RAB12, Member RAS Oncogene Family
Chromosome	18p11.22
Function	RAB12 encodes a member of the RAB family of small GTPases, which are key regulators of intracellular vesicle trafficking.
Primary Expression	the substantia nigra, and dysregulated RAB12 function may contribute to:
Molecular Weight	24 kDa
Pathways	mTOR, mtor
UniProt ID	Q96CM8
NCBI Gene ID	157556
Ensembl ID	ENSG00000139433
GeneCards	RAB12
Human Protein Atlas	RAB12
Associated Diseases	neurodegeneration
Interactions	JIP4, LRRK2, RAB10
SciDEX Hypotheses	Rab12 may better report chronic lysosomal stress b
KG Connections	13 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RAB12 — AlphaFold Q96CM8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RAB12 Gene

gene · 824 words

→

RAB12 Protein

protein · 768 words

→

Pathway Diagram

graph TD
    RAB12["RAB12"]
    ALS["ALS"]
    RAB12 -->|"regulates"| ALS
    Parkinson["Parkinson"]
    RAB12 -->|"phosphorylates"| Parkinson
    LRRK2["LRRK2"]
    LRRK2 -->|"interacts_with"| RAB12
    RAB10["RAB10"]
    RAB10 -->|"interacts_with"| RAB12
    Astrocyte["Astrocyte"]
    RAB12 -->|"expressed_in"| Astrocyte
    neurodegeneration["neurodegeneration"]
    RAB12 -->|"implicated_in"| neurodegeneration
    style RAB12 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
LRRK2	associated_with	protein	0.70
ALS	regulates	disease	0.65
Parkinson	phosphorylates	disease	0.65
oxidative stress response	participates_in	pathway	0.60
Astrocyte	expressed_in	cell_type	0.55
astrocytes	expressed_in	cell_type	0.55

Incoming (7)

Source	Relation	Type	Str
LRRK2	interacts_with	gene	0.60
RAB10	interacts_with	gene	0.60
JIP4	interacts_with	gene	0.60
JIP4	activates	gene	0.60
LRRK2	activates	gene	0.60
RAB10	activates	gene	0.60
LRRK2	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Rab12 may better report chronic lysosomal stress biology tha	0.670	neurodegeneration	Do pathogenic LRRK2 mutations amplify vo

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does LRRK2's role as a lysosomal volume sensor explain the pathogenic mechanism

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.666

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While the study establishes LRRK2 as a lysosomal swelling sensor and notes that

closed · Rounds: 4 · Score: 0.85 · 2026-04-16

Related Research

Hypotheses and analyses mentioning RAB12 in their description or question text

No additional research found