protein

RAB3C

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB3C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

19Outgoing

10Incoming

0Experiments

0Debates

Summary

RAB3C is a protein involved in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with ALS, Als. Connected to 21 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	RAB3C
Chromosome	22
Function	The RAB3C (RAB3C, Member RAS Oncogene Family) gene encodes a member of the Rab GTPase family, which is part of the Ras superfamily of small GTPases
Primary Expression	neuronal and neuroendocrine tissues, where it plays essential roles in regulated secretion, synaptic vesicle trafficking, and neurotransmitter release
Molecular Weight	30 kDa
Exons	Multiple exons spanning approximately 20 kb
Pathways	Glycolysis
Ensembl ID	ENSG00000172985
GeneCards	RAB3C
Human Protein Atlas	RAB3C
Location	22q12.3
Transcript	Protein-coding gene with multiple splice variants
Promoter	Contains neuron-specific regulatory elements
GTP-binding domain (G-domain)	Consists of five highly conserved G motifs (GxxxxGKST, DxxG, NKXD, T/SAK, WDTAGLE) that mediate nucleotide binding and hydrolysis
Switch I region	Undergoes dramatic conformational change upon GTP/GDP exchange, mediates effector protein binding
Associated Diseases	Als
Interactions	ATP, Il-6, Stat3
KG Connections	29 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

rab3c Gene

gene · 1302 words

→

Pathway Diagram

graph TD
    RAB3C["RAB3C"]
    Als{"Als"}
    RAB3C -->|"associated with"| Als
    ALS{"ALS"}
    RAB3C -->|"associated with"| ALS
    RAB5["RAB5"]
    RAB3C -->|"associated with"| RAB5
    RAB3B["RAB3B"]
    RAB3C -->|"associated with"| RAB3B
    RAB5A["RAB5A"]
    RAB3C -->|"associated with"| RAB5A
    RAB11B["RAB11B"]
    RAB3C -->|"associated with"| RAB11B
    RAB10["RAB10"]
    RAB3C -->|"associated with"| RAB10
    RAB3A["RAB3A"]
    RAB3C -->|"associated with"| RAB3A
    Exocytosis(["Exocytosis"])
    RAB3C -->|"associated with"| Exocytosis
    RAB27B["RAB27B"]
    RAB3C -->|"associated with"| RAB27B
    RAB4B["RAB4B"]
    RAB3C -->|"associated with"| RAB4B
    Synaptic_Vesicle(["Synaptic Vesicle"])
    RAB3C -->|"associated with"| Synaptic_Vesicle
    RAB4B -->|"associated with"| RAB3C
    RAB27B -->|"associated with"| RAB3C
    RAB3A -->|"associated with"| RAB3C
    RAB3B -->|"associated with"| RAB3C
    RAB10 -->|"associated with"| RAB3C
    RAB11B -->|"associated with"| RAB3C
    RAB5A -->|"associated with"| RAB3C
    RAB5 -->|"associated with"| RAB3C
    AND["AND"]
    AND -->|"associated with"| RAB3C
    style RAB3C fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (19)

Target	Relation	Type	Str
Als	associated_with	disease	0.65
Cancer	regulates	disease	0.65
ALS	associated_with	disease	0.65
Als	transports	disease	0.65
RAB4B	associated_with	gene	0.60
Synaptic Vesicle	associated_with	pathway	0.60
RAB27B	associated_with	gene	0.60
Fus	associated_with	protein	0.60
App	associated_with	protein	0.60
RAB5	associated_with	gene	0.60
RAB3B	associated_with	gene	0.60
RAB5A	associated_with	gene	0.60
RAB11B	associated_with	gene	0.60
RAB10	associated_with	gene	0.60
RAB3A	associated_with	gene	0.60
Stat3	activates	protein	0.60
Il-6	activates	protein	0.60
Exocytosis	associated_with	pathway	0.60
Glycolysis	activates	pathway	0.60

Incoming (10)

Source	Relation	Type	Str
proteins-rab3c-protein	describes	wiki	1.00
ATP	activates	gene	0.60
RAB4B	associated_with	gene	0.60
RAB27B	associated_with	gene	0.60
RAB3A	associated_with	gene	0.60
RAB3B	associated_with	gene	0.60
RAB10	associated_with	gene	0.60
RAB11B	associated_with	gene	0.60
RAB5A	associated_with	gene	0.60
RAB5	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAB3C in their description or question text

No additional research found