gene

RAB29

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB29: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

46Connections

3Hypotheses

0Analyses

31Outgoing

15Incoming

0Experiments

0Debates

Summary

RAB29 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, inhibits. Associated with Ms, Parkinson. Connected to 18 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RAB29
Full Name	RAS-Related Protein Rab-29
Chromosome	1q32.1
Function	is a member of the Rab GTPase family involved in intracellular vesicle trafficking, particularly within the lysosomal and endosomal pathways.
Primary Expression	Substantia nigra, Cortex, Hippocampus, Cerebellum
Molecular Weight	26 kDa
Amino Acids	236 aa
UniProt ID	O95793
NCBI Gene ID	8934
Ensembl ID	ENSG00000179406
OMIM	607423
GeneCards	RAB29
Human Protein Atlas	RAB29
Associated Diseases	Parkinson's Disease
Interactions	Actin, AND, LRRK2, PARKINSON, PARKINSON'S DISEASE, Proteins
SciDEX Hypotheses	RAB29 Is the Critical Molecular Switch That Determ
KG Connections	46 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RAB29 — AlphaFold O95793 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RAB29 — RAS-Related Protein Rab-29

gene · 1698 words

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RAB29 Protein

protein · 668 words

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Pathway Diagram

graph TD
    RAB29["RAB29"]
    Parkinson{"Parkinson"}
    RAB29 -->|"activates"| Parkinson
    RAB29 -->|"therapeutic target"| Parkinson
    Ms{"Ms"}
    RAB29 -->|"therapeutic target"| Ms
    LRRK2["LRRK2"]
    RAB29 -->|"activates"| LRRK2
    RAB10["RAB10"]
    RAB29 -->|"inhibits"| RAB10
    PARK16["PARK16"]
    RAB29 -->|"associated with"| PARK16
    RAB29 -->|"therapeutic target"| LRRK2
    GBA["GBA"]
    RAB29 -->|"therapeutic target"| GBA
    PARKINSON["PARKINSON"]
    RAB29 -->|"activates"| PARKINSON
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    RAB29 -->|"activates"| PARKINSON_S_DISEASE
    neurodegeneration["neurodegeneration"]
    RAB29 -->|"implicated in"| neurodegeneration
    LRRK2 -->|"activates"| RAB29
    PARK16 -->|"associated with"| RAB29
    RAB10 -->|"inhibits"| RAB29
    PARKINSON_S_DISEASE -->|"therapeutic target"| RAB29
    GUT_BRAIN_AXIS["GUT-BRAIN AXIS"]
    GUT_BRAIN_AXIS -->|"therapeutic target"| RAB29
    PARKINSON_S_DISEASE -->|"activates"| RAB29
    PARKINSON -->|"activates"| RAB29
    AND["AND"]
    AND -->|"activates"| RAB29
    style RAB29 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (31)

Target	Relation	Type	Str
LRRK2	operates in a common pathway with	gene	1.00
LRRK2	reduces endogenous	gene	1.00
LRRK2	recruits	gene	1.00
LRRK2 ankyrin domain	requires conserved residues within for Golgi recruitment and kinase activation	protein	1.00
LRRK2 Kinase Activity	modulates	mechanism	0.95
LRRK2	regulates	protein	0.90
Trans-Golgi Network	associated_with	organelle	0.90
Parkinson's Disease	associated_with	disease	0.90
Parkinson	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Parkinson	activates	disease	0.65
AND	activates	gene	0.60
GBA	therapeutic_target	gene	0.60
LRRK2	therapeutic_target	gene	0.60
PARKINSON	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
LRRK2	activates	gene	0.60
RAB10	inhibits	gene	0.60
PARK16	associated_with	gene	0.60
Actin	phosphorylates	protein	0.60
Parkinson's Disease	activates	disease	0.50
disease	activates	disease	0.50
PARKINSON'S	activates	concept	0.50
PARKINSON	interacts_with	gene	0.50
Parkinson's Disease	interacts_with	disease	0.50
disease	interacts_with	disease	0.50
PARKINSON'S	interacts_with	concept	0.50
Proteins	interacts_with	protein	0.50
PARKINSON	expressed_in	gene	0.50
PARKINSON'S	expressed_in	concept	0.50
PARK16	expressed_in	gene	0.50

Incoming (15)

Source	Relation	Type	Str
LRRK2 R1441G/C	more readily recruited to the Golgi and activated by	gene	1.00
LRRK2 Y1699C	more readily recruited to the Golgi and activated by	gene	1.00
PARKINSON'S DISEASE	activates	gene	0.60
PARKINSON	activates	gene	0.60
LRRK2	activates	gene	0.60
PARK16	associated_with	gene	0.60
RAB10	inhibits	gene	0.60
LRRK2	phosphorylates	entity	0.60
LRRK2	associated_with	entity	0.60
RAB10	phosphorylates	entity	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
GUT-BRAIN AXIS	therapeutic_target	gene	0.60
LRRK2	interacts_with	gene	0.50
LRRK2	expressed_in	gene	0.50
LRRK2	inhibits	gene	0.50

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
G2019S Acts as Lysosomal Volume-Sensing Amplifier via Enhanc	0.730	neurodegeneration	Do pathogenic LRRK2 mutations amplify vo
RAB29 Is the Critical Molecular Switch That Determines Wheth	0.710	neurodegeneration	Do pathogenic LRRK2 mutations amplify vo
LRRK2 G2019S Uncouples RAB29-Dependent Spatial Control from	0.640	neurodegeneration	Do pathogenic LRRK2 mutations amplify vo

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAB29 in their description or question text

No additional research found