gene

PARK16

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PARK16: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

20Connections

0Hypotheses

0Analyses

11Outgoing

9Incoming

0Experiments

0Debates

Summary

PARK16 is a Parkinson's disease risk locus containing multiple genes including RAB7L1, associated with lysosomal trafficking, autophagy, and dopaminergic neuron survival.

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🧬 Gene Info

Gene Symbol	PARK16
Full Name	Parkinson's Disease Locus 16
Chromosome	1q32
Amino Acids	220 aa
Pathways	Role of RAB7L1
UniProt ID	RAB7L1
NCBI Gene ID	493856
Ensembl ID	ENSG00000109189
GeneCards	PARK16
Human Protein Atlas	PARK16
Associated Diseases	Parkinson, Parkinson's disease
Interactions	Actin, AND, LRRK2, PARKINSON'S DISEASE, RAB10
KG Connections	20 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PARK16 — AlphaFold RAB7L1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PARK16 - Parkinson's Disease Locus 16

gene · 1225 words

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PARK16 Protein - PARK16

protein · 659 words

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Pathway Diagram

graph TD
    PARK16["PARK16"]
    Parkinson{"Parkinson"}
    PARK16 -->|"associated with"| Parkinson
    RAB10["RAB10"]
    PARK16 -->|"activates"| RAB10
    RAB29["RAB29"]
    PARK16 -->|"associated with"| RAB29
    LRRK2["LRRK2"]
    PARK16 -->|"associated with"| LRRK2
    neurodegeneration["neurodegeneration"]
    PARK16 -->|"implicated in"| neurodegeneration
    RAB29 -->|"associated with"| PARK16
    LRRK2 -->|"associated with"| PARK16
    RAB10 -->|"activates"| PARK16
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"activates"| PARK16
    PARKINSON["PARKINSON"]
    PARKINSON -->|"associated with"| PARK16
    AND["AND"]
    AND -->|"activates"| PARK16
    style PARK16 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

Target	Relation	Type	Str
Parkinson	associated_with	disease	0.65
Actin	activates	protein	0.60
AND	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
PARKINSON	associated_with	gene	0.60
Parkinson's disease	associated_with	disease	0.60
RAB10	activates	gene	0.60
RAB29	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
PARKINSON	expressed_in	gene	0.50
PARKINSON'S	expressed_in	concept	0.50

Incoming (9)

Source	Relation	Type	Str
LRRK2	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
PARKINSON	associated_with	gene	0.60
RAB29	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
RAB10	activates	gene	0.60
LRRK2	expressed_in	gene	0.50
RAB29	expressed_in	gene	0.50
LRRK2	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PARK16 in their description or question text

No additional research found