gene 2,789 words KG: PLCG2
Contents

PLCG2 Gene

🧬 Gene Info
Gene SymbolPLCG2
Full NamePhospholipase C Gamma 2
Chromosome16q23.3
Protein TypeEnzyme
Primary Expressionhematopoietic cells and microglia
Molecular Weight150 kDa
Amino Acids265 aa
PathwaysMAPK
UniProt IDP16885
NCBI Gene ID5336
Ensembl IDENSG00000197943
OMIM600220
GeneCardsPLCG2
Human Protein AtlasPLCG2
Associated DiseasesAD, AD risk, Aging, Als, Alzheimer, Alzheimer's disease
InteractionsActin, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID, Amyloid Beta
SciDEX HypothesesPLCG2 Allosteric Modulation as a Precision Therape
KG Connections386 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (25)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
TREM2-Dependent Microglial Senescence Transition
Score: 0.95
CYP46A1 Overexpression Gene Therapy
Score: 0.92

Related Analyses (11)

Which cell types show the most significant expression change
neurodegeneration · completed
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

See Also (10)

Packard Center for ALS Research
institution · KG edge: associated_with
ABCA7 (Redirect)
redirect · KG edge: associated_with
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

DOT1L contributes_to PLCG2
PLCG2 contributes_to ABCB1
PLCG2 contributes_to PARP1
ABCB1 contributes_to PLCG2
PARP1 contributes_to PLCG2
PLCG2 contributes_to DOT1L
PLCG2 implicated_in cancer
PLCG2 implicated_in carcinoma
PLCG2 implicated_in ovarian cancer
TREM2 associated_with PLCG2

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