gene 1,289 words KG: NUP62
Contents

NUP62 — Nucleoporin 62

🧬 Gene Info
Gene SymbolNUP62
Full NameNucleoporin 62
Chromosome19q13.33
FunctionThis trimeric complex forms the constriction ring of the NPC and is essential for
Molecular Weight62 kDa
Amino Acids522 aa
UniProt IDP37198
NCBI Gene ID23636
Ensembl IDENSG00000213024
OMIM605815
GeneCardsNUP62
Human Protein AtlasNUP62
Selective permeabilityCreating the FG-hydrogel that discriminates cargo by size and transport receptor binding
NPC biogenesisRequired for de novo NPC assembly during interphase and post-mitotic NPC reconstitution
NPC maintenanceTurnover and replacement of damaged nucleoporins in long-lived neurons
Associated DiseasesHuntington's Disease, Infantile Bilateral Striatal Necrosis
DatabasesGeneCardsHPASTRING

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Related Hypotheses (7)

Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61

Related Analyses (7)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
mitochondrial-dysfunction-neurodegeneration-comparison
disease · Pages share 4 hypotheses
Familial vs Sporadic Neurodegeneration Comparison
disease · Pages share 4 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 4 hypotheses
TARDBP Mutations in Amyotrophic Lateral Sclerosis
disease · Pages share 4 hypotheses

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