| Gene Symbol | NRF2 |
| Full Name | KEAP1 Oxidative Stress Response Pathway |
| Chromosome | 2q31.2 |
| Protein Family | Cap'n'Collar (CNC) bZIP transcription factor |
| Function | Basal state: Keap1 homodimer binds NRF2 via the DLG and ETGE motifs, serving as a substrate adapter for the Cul3-RING ubiquitin E3 ligase complex. |
| Molecular Weight | 68 kDa |
| Amino Acids | 605 aa |
| Pathways | Akt, Apoptosis, Autophagy, Cell Cycle, Chaperone |
| GeneCards | NRF2 |
| Human Protein Atlas | NRF2 |
| Neh (NRF2-ECH) domains | Six conserved domains (Neh1-Neh6) that mediate protein-protein interactions |
| Basic region | DNA-binding domain that recognizes antioxidant response elements (ARE) |
| Transactivation domain | Regulates transcriptional activity |
| BTB domain | Mediates homodimerization and interaction with CUL3 |
| Intervening region (IVR) | Contains key cysteine sensors |
| Associated Diseases | aging, Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | 4-octyl itaconate, 4OI, ALGERNON2, Alpha-Tocopherol, Artesunate, ATORVASTATIN |
| Interactions | ABCG2, ACETYLCHOLINE, ACHE, ACOD1, ACSL4, Actin |
| KG Connections | 3450 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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