Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about COX15: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | COX15 |
| Full Name | Cytochrome C Oxidase Assembly Factor 15 |
| Chromosome | 10q24.2 |
| Function | COX15 plays a crucial role in the final steps of heme A synthesis |
| Primary Expression | all tissues with high energy demands: - Heart and skeletal muscle (highest expression) - Brain (neurons and glia) - Liver and kid |
| Subcellular Localization | </strong></td><td>Mitochondrial inner membrane</td></tr> [@ryan2022] |
| Molecular Weight | 42 kDa |
| UniProt ID | [Q7B433](https://www.uniprot.org/uniprot/Q7B433) |
| Ensembl ID | ENSG00000074981 |
| OMIM | 603646 |
| GeneCards | COX15 |
| Human Protein Atlas | COX15 |
| N-terminal Transmembrane Helices | 3-4 predicted transmembrane domains anchoring the protein to the inner membrane |
| Catalytic Domain | Faces the mitochondrial matrix and contains the active site for heme A biosynthesis |
| Heme Binding Site | Contains conserved cysteine residues for heme coordination |
| Associated Diseases | neurodegeneration |
| Interactions | ATP, COX4I1, COX7A1, COX8A, NDUFA12, NDUFA5 |
| KG Connections | 21 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["COX15"]
N1["ATP"]
N0 -->|"activates"| N1
N2["ACSL5"]
N0 -->|"associated with"| N2
N3["RPL4"]
N0 -->|"associated with"| N3
N4["Ras"]
N0 -->|"activates"| N4
N5["PPP1R7"]
N5 -->|"associated with"| N0
N6["ABCB1"]
N6 -->|"associated with"| N0
N7["PEX3"]
N7 -->|"associated with"| N0
N8["VPS33A"]
N8 -->|"associated with"| N0
N9["VPS16"]
N9 -->|"associated with"| N0
N10["neurodegeneration"]
N0 -->|"implicated in"| N10
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 gene
class N2 gene
class N3 gene
class N4 protein
class N5 gene
class N6 gene
class N7 gene
class N8 gene
class N9 gene| Target | Relation | Type | Str |
|---|---|---|---|
| OXPHOS | involved_in | pathway | 0.90 |
| Oxidative Phosphorylation | involved_in | pathway | 0.90 |
| COX7A1 | inhibits | gene | 0.60 |
| COX8A | inhibits | gene | 0.60 |
| NDUFA12 | inhibits | gene | 0.60 |
| NDUFA5 | inhibits | gene | 0.60 |
| COX4I1 | inhibits | gene | 0.60 |
| NDUFS4 | inhibits | gene | 0.60 |
| ATP | activates | gene | 0.60 |
| ACSL5 | associated_with | gene | 0.60 |
| Ras | activates | protein | 0.60 |
| NDUFS1 | inhibits | gene | 0.60 |
| RPL4 | associated_with | gene | 0.60 |
| COX4I1 | co_expressed_with | gene | 0.50 |
| COX7A1 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning COX15 in their description or question text
No additional research found