gene

MTDNA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MTDNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1156Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MTDNA is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 733 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MTDNA
Primary Expression	Spinal Cord
Pathways	Mitophagy, Nf-Κb, Oxidative Stress, Apoptosis, Autophagy
GeneCards	MTDNA
Human Protein Atlas	MTDNA
Associated Diseases	Aging, Als, Alzheimer, Autism, Autoimmune
Interactions	Actin, AGING, AIM2, AKT, ALS, ALZHEIMER
KG Connections	1121 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    MTDNA["MTDNA"] -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    MTDNA["MTDNA"] -->|"activates"| Als["Als"]
    MTDNA["MTDNA"] -->|"activates"| Inflammation["Inflammation"]
    MTDNA["MTDNA"] -->|"activates"| Aging["Aging"]
    MTDNA["MTDNA"] -->|"activates"| Ms["Ms"]
    MTDNA["MTDNA"] -->|"associated"| Carcinoma["Carcinoma"]
    TDP43["TDP43"] -->|"causes"| MTDNA["MTDNA"]
    STING["STING"] -->|"activates"| MTDNA["MTDNA"]
    CGAS["CGAS"] -->|"activates"| MTDNA["MTDNA"]
    GPX4["GPX4"] -->|"associated"| MTDNA["MTDNA"]
    style MTDNA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (708)

Target	Relation	Type	Str
DNA	activates	gene	1.00
MITOCHONDRIA	associated_with	gene	1.00
Als	activates	disease	1.00
Inflammation	activates	disease	1.00
DNA	associated_with	gene	1.00
STING	activates	gene	1.00
Oxidative Stress	activates	pathway	1.00
CGAS-STING	activates	gene	1.00
MITOCHONDRIA	activates	gene	1.00
Mitophagy	activates	pathway	1.00
Mitochondrial Function	activates	pathway	1.00
Autophagy	activates	pathway	1.00
Inflammation	inhibits	disease	0.95
Neuroinflammation	activates	disease	0.95
Neurodegeneration	activates	disease	0.95
13 PROTEINS	encodes	protein	0.95
Cancer	therapeutic_target	disease	0.95
Oxidative Phosphorylation	associated_with	process	0.95
Oxidative Phosphorylation	involved_in	process	0.95
CGAS	activates	protein	0.94
mitochondrial respiration	regulates	process	0.90
mitochondrial proteome	associated_with	protein	0.90
Mitochondrial Disorders	associated_with	disease	0.90
Mitochondrial Disorders	biomarker_for	disease	0.90
DNA	inhibits	gene	0.90
NF-κB	activates	protein	0.88
IL-6	activates	protein	0.88
Cancer	activates	disease	0.85
Neurodegeneration	associated_with	disease	0.85
Als	therapeutic_target	disease	0.85
Senescence	activates	disease	0.85
Als	inhibits	disease	0.85
Ischemia	inhibits	disease	0.85
Parkinson	activates	disease	0.85
Aging	activates	disease	0.85
Neuroinflammation	promotes	process	0.85
Alzheimer	activates	disease	0.85
Als	associated_with	disease	0.85
cGAS-STING Pathway	activates	pathway	0.85
Mitochondrial Proteome	contributes_to	protein	0.80
Mitochondrial Function	involved_in	process	0.80
Neuroinflammation	associated_with	process	0.80
NLRP3	activates	protein	0.80
Mitochondrial Function	regulates	process	0.80
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.80
Oxidative Stress	associated_with	pathway	0.80
Nf-Κb	activates	pathway	0.80
AUTOPHAGY	activates	gene	0.80
Apoptosis	activates	pathway	0.80
GENES	associated_with	gene	0.80

Incoming (448)

Source	Relation	Type	Str
PINK1	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
CGAS	activates	gene	1.00
ROS	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
MITOCHONDRIAL DNA	associated_with	gene	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
MITOCHONDRIAL DNA	activates	gene	1.00
MITOPHAGY	activates	gene	1.00
GENES	activates	gene	1.00
MITOCHONDRIAL DNA	causes	gene	1.00
DNA	activates	gene	1.00
Mtros	downregulates	compound	0.90
zalcitabine	causes	drug	0.90
TFAM	regulates	protein	0.90
mtROS	associated_with	process	0.90
oxidative stress	causes	process	0.90
TFAM	binds_to	protein	0.90
NEURODEGENERATION	activates	gene	0.90
APOPTOSIS	activates	gene	0.90
NEURODEGENERATIVE DISEASES	activates	gene	0.90
TFAM Knockdown	downregulates	process	0.85
Mitochondrial Fission	causes	process	0.85
POLG	involved_in	gene	0.85
VDAC	mediates	protein	0.80
CGAS	binds	gene	0.80
IMPAIRED_MITOPHAGY	increases	biological_process	0.80
MITOCHONDRIAL_DYSFUNCTION	increases	biological_process	0.80
POLG	regulates	protein	0.80
GENES	associated_with	gene	0.80
OXIDATIVE STRESS	inhibits	gene	0.80
PARKIN	activates	gene	0.80
AUTOPHAGY	activates	gene	0.80
NF-ΚB	activates	gene	0.80
NEURODEGENERATION	associated_with	gene	0.80
CYTOKINES	activates	gene	0.80
INFLAMMATION	inhibits	gene	0.80
NEUROINFLAMMATION	activates	gene	0.80
CANCER	therapeutic_target	gene	0.80
ATM	modulates	protein	0.75
TDP43	causes	protein	0.72
IL-6	activates	gene	0.70
EXERCISE	activates	gene	0.70
AMPK	inhibits	gene	0.70
IRF3	activates	gene	0.70
SIRT3	activates	gene	0.70
OXIDATIVE STRESS	associated_with	gene	0.70
MITOCHONDRIAL DNA	inhibits	gene	0.70
CANCER	causes	gene	0.70
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.70

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.804	neurodegeneration	What are the mechanisms by which gut mic
Severely Depleted mtDNA and Impaired OXPHOS Defines Senescen	0.520	neurodegeneration	How can senescent microglia be molecular

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MTDNA in their description or question text

No additional research found