gene

CALB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CALB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

0Hypotheses

0Analyses

47Outgoing

25Incoming

0Experiments

0Debates

Summary

CALB2 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, contributes to, implicated in. Associated with Autoimmune, Cancer, Depression. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CALB2
Chromosome	16q22.2 [@wong2025]
Protein Type	Gene
Function	CALB2 encodes calretinin, a calcium-binding protein of the EF-hand family.
Primary Expression	specific neuronal populations and is considered a neuroprotective molecule due to its calcium-buffering capacity
Pathways	Mapk
UniProt ID	P22676
NCBI Gene ID	794
Ensembl ID	ENSG00000171331
GeneCards	CALB2
Human Protein Atlas	CALB2
Large Olivary Soma	Neurons have medium-sized cell bodies (15-25 μm diameter) with densely packed dendritic arborizations
Lamellar Architecture	The characteristic folded (lamellar) structure maximizes surface area for synaptic contacts
Dense Synaptic Coverage	Each Purkinje cell receives input from multiple PO neurons via climbing fiber synapses on proximal dendrites
Gap Junction Coupling	Electrical synapses between neighboring olivary neurons synchronize firing patterns
Associated Diseases	Huntington, neurodegeneration
Interactions	AND, ASTROCYTES, Bdnf, BDNF, CALB1, CHRNA6
KG Connections	72 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CALB2 — AlphaFold P22676 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

Principal Olive Neurons

cell · 882 words

→

CALB2 Gene

gene · 688 words

→

Pathway Diagram

graph TD
    CALB2["CALB2"]
    Schizophrenia{"Schizophrenia"}
    CALB2 -->|"inhibits"| Schizophrenia
    Cancer{"Cancer"}
    CALB2 -->|"contributes to"| Cancer
    Depression{"Depression"}
    CALB2 -->|"inhibits"| Depression
    Ms{"Ms"}
    CALB2 -->|"inhibits"| Ms
    Autoimmune{"Autoimmune"}
    CALB2 -->|"contributes to"| Autoimmune
    RAB3B["RAB3B"]
    CALB2 -->|"inhibits"| RAB3B
    Epigenetic(["Epigenetic"])
    CALB2 -->|"inhibits"| Epigenetic
    Notch(["Notch"])
    CALB2 -->|"contributes to"| Notch
    neurodegeneration["neurodegeneration"]
    CALB2 -->|"implicated in"| neurodegeneration
    GFAP["GFAP"]
    GFAP -->|"inhibits"| CALB2
    CHRNA6["CHRNA6"]
    CHRNA6 -->|"inhibits"| CALB2
    CANCER["CANCER"]
    CANCER -->|"contributes to"| CALB2
    style CALB2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (47)

Target	Relation	Type	Str
Ataxia	regulates	disease	0.65
Spinocerebellar Ataxia	regulates	disease	0.65
Schizophrenia	inhibits	disease	0.65
Cancer	contributes_to	disease	0.65
Depression	inhibits	disease	0.65
Huntington	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ms	inhibits	disease	0.65
Autoimmune	contributes_to	disease	0.65
Neuron	regulates	cell_type	0.60
AND	inhibits	gene	0.60
CALB1	inhibits	gene	0.60
PVALB	inhibits	gene	0.60
S100B	activates	gene	0.60
GFAP	activates	gene	0.60
Epigenetic	inhibits	pathway	0.60
Notch	contributes_to	pathway	0.60
HUNTINGTON	regulates	gene	0.60
Neuron	activates	cell_type	0.60
Astrocyte	activates	cell_type	0.60
AND	activates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
Huntington	associated_with	disease	0.60
Mapk	activates	pathway	0.60
ASTROCYTES	activates	gene	0.60
GAD1	inhibits	gene	0.60
neurodegeneration	activates	disease	0.60
neurodegeneration	associated_with	disease	0.60
RAB3B	inhibits	gene	0.60
DNAJC6	regulates	gene	0.60
ROCK2	activates	gene	0.60
DNAJC5	activates	gene	0.60
FOS	activates	gene	0.60
CREB1	activates	gene	0.60
BDNF	inhibits	gene	0.60
Rb	regulates	protein	0.60
App	regulates	protein	0.60
EGR1	activates	gene	0.60
NTRK2	inhibits	gene	0.60
MAPK1	activates	gene	0.60
NTRK3	activates	gene	0.60
Bdnf	inhibits	protein	0.60
Astrocyte	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
Proteins	inhibits	protein	0.50
DNAJC5	co_expressed_with	gene	0.50
DNAJC6	co_expressed_with	gene	0.50

Incoming (25)

Source	Relation	Type	Str
GFAP	activates	gene	0.60
S100B	activates	gene	0.60
MAPK1	activates	gene	0.60
CREB1	activates	gene	0.60
NTRK3	activates	gene	0.60
EGR1	activates	gene	0.60
FOS	activates	gene	0.60
NTRK2	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
GAD1	inhibits	gene	0.60
NTF3	activates	gene	0.60
PVALB	inhibits	gene	0.60
CANCER	contributes_to	gene	0.60
DNAJC6	regulates	gene	0.60
ROCK2	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
GFAP	inhibits	gene	0.60
CHRNA6	inhibits	gene	0.60
SYNAPSE	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
HUNTINGTON'S DISEASE	regulates	gene	0.60
HUNTINGTON	regulates	gene	0.60
Neurodegeneration	activates	disease	0.50
CALB1	inhibits	gene	0.50
DNAJC5	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CALB2 in their description or question text

No additional research found