gene

NTF4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NTF4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

4Outgoing

11Incoming

0Experiments

0Debates

Summary

NTF4 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, implicated in. Associated with Inflammation, Ms, Schizophrenia. Connected to 16 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NTF4
Full Name	Neurotrophin-4
Chromosome	19p13.3
Function	Neurotrophin-4 (NT-4) is the least studied member of the classical neurotrophin family, which includes NGF, BDNF, and NT-3.
Molecular Weight	30 kDa
Amino Acids	230 aa
Pathways	PI3K, MAPK
UniProt ID	P34130
NCBI Gene ID	4903
Ensembl ID	ENSG00000185655
GeneCards	NTF4
Human Protein Atlas	NTF4
Associated Diseases	Alzheimer's Disease, Parkinson's Disease, Glaucoma
Interactions	BDNF, CDH1, CTNNB1, CYTOKINES, DISC1, NEUROTOXICITY
KG Connections	15 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NTF4 — AlphaFold P34130 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NTF4 — Neurotrophin-4

gene · 769 words

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NTF4 Protein

protein · 4726 words

→

Pathway Diagram

graph TD
    NTF4["NTF4"]
    Ms{"Ms"}
    NTF4 -->|"interacts with"| Ms
    Inflammation{"Inflammation"}
    NTF4 -->|"interacts with"| Inflammation
    Schizophrenia{"Schizophrenia"}
    NTF4 -->|"interacts with"| Schizophrenia
    Immune_Response(["Immune Response"])
    NTF4 -->|"interacts with"| Immune_Response
    neurodegeneration["neurodegeneration"]
    NTF4 -->|"implicated in"| neurodegeneration
    NTRK2["NTRK2"]
    NTRK2 -->|"interacts with"| NTF4
    SRC["SRC"]
    SRC -->|"interacts with"| NTF4
    CTNNB1["CTNNB1"]
    CTNNB1 -->|"interacts with"| NTF4
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"interacts with"| NTF4
    STAT3["STAT3"]
    STAT3 -->|"interacts with"| NTF4
    TRAF6["TRAF6"]
    TRAF6 -->|"interacts with"| NTF4
    BDNF["BDNF"]
    BDNF -->|"interacts with"| NTF4
    DISC1["DISC1"]
    DISC1 -->|"interacts with"| NTF4
    NEUROTOXICITY["NEUROTOXICITY"]
    NEUROTOXICITY -->|"interacts with"| NTF4
    CDH1["CDH1"]
    CDH1 -->|"interacts with"| NTF4
    NGFR["NGFR"]
    NGFR -->|"interacts with"| NTF4
    style NTF4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

Target	Relation	Type	Str
Ms	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Schizophrenia	interacts_with	disease	0.65
Immune Response	interacts_with	pathway	0.60

Incoming (11)

Source	Relation	Type	Str
CYTOKINES	interacts_with	gene	0.60
NEUROTOXICITY	interacts_with	gene	0.60
CDH1	interacts_with	gene	0.60
NTRK2	interacts_with	gene	0.60
SRC	interacts_with	gene	0.60
CTNNB1	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
TRAF6	interacts_with	gene	0.60
BDNF	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
NGFR	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NTF4 in their description or question text

No additional research found