gene 2,414 words KG: NTRK2
Contents

NTRK2 Gene

🧬 Gene Info
Gene SymbolNTRK2
Full NameNeurotrophic Receptor Tyrosine Kinase 2
Chromosome9q22.1
Protein TypeReceptor
Functionencodes the BDNF (brain-derived neurotrophic factor) receptor, also known as TrkB
PathwaysPI3K, MAPK, mTOR
UniProt IDQ16620
NCBI Gene ID4915
Ensembl IDENSG00000148018
OMIM600456
GeneCardsNTRK2
Human Protein AtlasNTRK2
Associated DiseasesAlzheimer, Alzheimer's disease, disease
InteractionsADCYAP1R1, ALZHEIMER, APOPTOSIS, ASTROCYTES, ATP1A2, Bdnf
KG Connections245 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

APOE-Dependent Autophagy Restoration
Score: 0.88
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Astrocytes
cell · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: associated_with
Astrocytes
entity · KG edge: activates
ATP1A2 Gene
gene · KG edge: associated_with
BDNF Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

BDNF activates NTRK2
TRKB activates NTRK2
NTRK2 regulates FGF7
NTRK2 activates BDNF
NTRK2 activates TRKB
CDKN2A inhibits NTRK2
TLR4 associated_with NTRK2
TNC associated_with NTRK2
NTRK2 inhibits PAK1
NTRK2 inhibits WNT7A

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