| Gene Symbol | NR1H3 |
| Full Name | Nuclear Receptor Subfamily 1 Group H Member 3 |
| Chromosome | 11p11.2 |
| Protein Type | Transcription Factor |
| Function | is a ligand-activated transcription factor that plays a critical role in regulating cholesterol homeostasis, lipid metabolism, and inflammatory responses<sup>[1]</sup>. |
| Primary Expression | multiple tissues including the brain, liver, kidney, and adipose tissue<sup>[2]</sup> |
| Amino Acids | 445 aa |
| Exons | 11 |
| Pathways | Autophagy, Chaperone, Cholesterol, ER stress, Er Stress |
| UniProt ID | [Q9GZN5](https://www.uniprot.org/uniprot/Q9GZN5) |
| Ensembl ID | ENSG00000125448 |
| GeneCards | NR1H3 |
| Human Protein Atlas | NR1H3 |
| Associated Diseases | Cancer, Carcinoma, Lung Cancer, Melanoma, Tumor |
| Known Drugs/Compounds | rapamycin |
| Interactions | ABCD1, ABCD3, ACOX1, Adiponectin, ADIPOQ, AMPK |
| KG Connections | 238 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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