concept

DTX3L

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DTX3L: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

19Outgoing

12Incoming

0Experiments

0Debates

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💡 Concept Info

Name	DTX3L
Key Genes/Proteins	AND, DTX1, GENES, KLF2, NOTCH, NOTCH1
Related Pathways	Angiogenesis, Notch

Pathway Diagram

graph TD
    DTX3L["DTX3L"]
    DTX3L -->|"regulates"| ORAI1["ORAI1"]
    DTX3L -->|"regulates"| NOTCH1["NOTCH1"]
    DTX3L -->|"activates"| Angiogenesis["Angiogenesis"]
    DTX3L -->|"activates"| Notch["Notch"]
    DTX3L -->|"regulates"| KLF2["KLF2"]
    DTX3L -->|"activates"| PIEZO1["PIEZO1"]
    DTX3L -->|"regulates"| GENES["GENES"]
    ORAI1 -->|"regulates"| DTX3L
    DTX1["DTX1"] -->|"regulates"| DTX3L
    GENES -->|"regulates"| DTX3L
    KLF2 -->|"regulates"| DTX3L
    PIEZO1 -->|"activates"| DTX3L
    UBIQUITIN["UBIQUITIN"] -->|"regulates"| DTX3L
    NOTCH1 -->|"regulates"| DTX3L
    AND["AND"] -->|"regulates"| DTX3L

Outgoing (19)

Target	Relation	Type	Str
Endothelial	regulates	cell_type	0.60
NOTCH1	activates	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
ORAI1	regulates	gene	0.60
NOTCH1	regulates	gene	0.60
Angiogenesis	activates	pathway	0.60
Notch	activates	pathway	0.60
KLF2	regulates	gene	0.60
PIEZO1	activates	gene	0.60
Angiogenesis	regulates	pathway	0.60
GENES	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
KLF2	activates	gene	0.60
DTX1	regulates	gene	0.60
NOTCH	activates	gene	0.60
AND	regulates	gene	0.60
PIEZO	activates	gene	0.60
Endothelial Cell	expressed_in	cell_type	0.55

Incoming (12)

Source	Relation	Type	Str
ORAI1	regulates	gene	0.66
NOTCH	activates	gene	0.60
PIEZO	activates	gene	0.60
DTX1	activates	gene	0.60
UBIQUITIN	regulates	gene	0.60
NOTCH1	regulates	gene	0.60
AND	regulates	gene	0.60
DTX1	regulates	gene	0.60
GENES	regulates	gene	0.60
KLF2	regulates	gene	0.60
PIEZO1	activates	gene	0.60
ZO1	associated_with	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DTX3L in their description or question text

No additional research found