Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DTX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | DTX1 |
| Key Genes/Proteins | AND, DTX3L, GENES, KLF2, NOTCH, NOTCH1 |
| Related Pathways | Angiogenesis, Notch |
graph TD
DTX1["DTX1"]
DTX1 -->|"involved_in"| Lymphatic_Sprouting["Lymphatic Sprouting"]
DTX1 -->|"regulates"| GENES["GENES"]
DTX1 -->|"regulates"| KLF2["KLF2"]
DTX1 -->|"regulates"| PIEZO1["PIEZO1"]
DTX1 -->|"regulates"| DTX3L["DTX3L"]
DTX1 -->|"regulates"| ORAI1["ORAI1"]
DTX1 -->|"regulates"| NOTCH1["NOTCH1"]
DTX1 -->|"activates"| Angiogenesis["Angiogenesis"]
ORAI1 -->|"regulates"| DTX1
KLF2 -->|"regulates"| DTX1
NOTCH1 -->|"regulates"| DTX1
PIEZO1 -->|"regulates"| DTX1
DTX3L -->|"regulates"| DTX1
GENES -->|"regulates"| DTX1
UBIQUITIN["UBIQUITIN"] -->|"regulates"| DTX1
AND["AND"] -->|"regulates"| DTX1| Target | Relation | Type | Str |
|---|---|---|---|
| Lymphatic Sprouting | involved_in | process | 0.85 |
| NOTCH | regulates | gene | 0.60 |
| PIEZO | regulates | gene | 0.60 |
| Endothelial | regulates | cell_type | 0.60 |
| DTX3L | activates | gene | 0.60 |
| KLF2 | activates | gene | 0.60 |
| NOTCH1 | activates | gene | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| endothelial cells | expressed_in | cell_type | 0.60 |
| GENES | regulates | gene | 0.60 |
| KLF2 | regulates | gene | 0.60 |
| PIEZO1 | regulates | gene | 0.60 |
| DTX3L | regulates | gene | 0.60 |
| ORAI1 | regulates | gene | 0.60 |
| NOTCH1 | regulates | gene | 0.60 |
| Angiogenesis | activates | pathway | 0.60 |
| Notch | regulates | pathway | 0.60 |
| Angiogenesis | regulates | pathway | 0.60 |
| UBIQUITIN | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| Endothelial Cell | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DTX1 in their description or question text
No additional research found