gene 1,538 words KG: NGF
Contents

NGF Gene

🧬 Gene Info
Gene SymbolNGF
Full NameNerve Growth Factor
Chromosome1p13.1
Protein FamilyNeurotrophin family
Primary ExpressionPrimarily in nociceptive sensory neurons, cholinergic basal forebrain neurons, sympathetic ganglia
Molecular Weight30 kDa
Amino Acids120 aa
Exons3
PathwaysPI3K, MAPK
UniProt IDP01138
NCBI Gene ID4800
Ensembl IDENSG00000111665
OMIM162030
GeneCardsNGF
Human Protein AtlasNGF
Associated DiseasesAls, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, ANGIOGENESIS
Known Drugs/Compoundsaducanumab, lecanemab, metformin
InteractionsACHE, Actin, ADRB2, AGING, Akt, AKT
KG Connections762 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (30)

Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
PARP1 Inhibition Therapy
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Ocular Immune Privilege Extension
Score: 0.69
Ganglioside Rebalancing Therapy
Score: 0.69
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
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Related Analyses (11)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (2)

Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40
Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40

See Also (4)

ABCA7 (Redirect)
redirect · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits

Knowledge Graph (12 edges)

NGF activates CHR2
NGF activates BDNF
TRKA interacts_with NGF
NRP1 activates NGF
NGF inhibits GAIN
NGF activates DCX
NGF expressed_in BDNF
NGF activates HES1
NGF activates NESTIN
NGF activates NOTCH1

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