concept

DEMENTIA WITH LEWY BODIES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DEMENTIA WITH LEWY BODIES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

0Hypotheses

0Analyses

9Outgoing

36Incoming

0Experiments

0Debates

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💡 Concept Info

Name	DEMENTIA WITH LEWY BODIES

Pathway Diagram

graph TD
    DEMENTIA_WITH_LEWY_BODIES[DEMENTIA WITH LEWY BODIES]
    DEMENTIA_WITH_LEWY_BODIES -->|affects| neurons[neurons]
    DEMENTIA_WITH_LEWY_BODIES -->|affects| prefrontal_cortex[prefrontal cortex]
    DEMENTIA_WITH_LEWY_BODIES -->|affects| locus_coeruleus[locus coeruleus]
    DEMENTIA_WITH_LEWY_BODIES -->|affects| substantia_nigra[substantia nigra]
    DEMENTIA_WITH_LEWY_BODIES -->|affects| cortex[cortex]
    DEMENTIA_WITH_LEWY_BODIES -->|affects| microglia[microglia]
    DEMENTIA_WITH_LEWY_BODIES -->|affects| oligodendrocytes[oligodendrocytes]
    DEMENTIA_WITH_LEWY_BODIES -->|involves| synaptic_plasticity[synaptic plasticity]
    DEMENTIA_WITH_LEWY_BODIES -->|affects| hippocampus[hippocampus]
    SNCA[SNCA] -->|implicated in| DEMENTIA_WITH_LEWY_BODIES
    DDC[DDC] -.biomarker for.-> DEMENTIA_WITH_LEWY_BODIES
    MSR1[MSR1] -->|upregulates| DEMENTIA_WITH_LEWY_BODIES
    __SYNUCLEIN[Α-SYNUCLEIN] -.biomarker for.-> DEMENTIA_WITH_LEWY_BODIES
    Microglia[Microglia] -->|involved_in| DEMENTIA_WITH_LEWY_BODIES
    __synuclein_aggregation[α-synuclein aggregation] -->|causes| DEMENTIA_WITH_LEWY_BODIES

Outgoing (9)

Target	Relation	Type	Str
neurons	affects	cell_type	0.80
locus coeruleus	affects	brain_region	0.60
cortex	affects	brain_region	0.60
microglia	affects	cell_type	0.60
oligodendrocytes	affects	cell_type	0.60
substantia nigra	affects	brain_region	0.60
prefrontal cortex	affects	brain_region	0.60
synaptic plasticity	involves	pathway	0.60
hippocampus	affects	brain_region	0.60

Incoming (36)

Source	Relation	Type	Str
SNCA	associated_with	gene	1.00
Neuronal α-synuclein Disease	associated_with	disease	0.95
SNCA	associated_with	protein	0.95
DDC	biomarker_for	protein	0.95
Α-SYNUCLEIN	biomarker_for	protein	0.95
SNCA	implicated_in	protein	0.95
MSR1	upregulates	gene	0.95
Microglia	associated_with	cell_type	0.90
SNCA	causes	protein	0.90
MSR1	upregulates	gene	0.90
α-synuclein aggregation	causes	process	0.85
Parkinson's Disease Dementia	associated_with	disease	0.85
Inflammation	involved_in	process	0.80
PINK1	associated_with	gene	0.80
GBA1	associated_with	gene	0.80
APOE-Ε4	associated_with	gene	0.80
α-synuclein aggregation	associated_with	process	0.70
alpha-synuclein	causes	protein	0.70
DDC	treats	gene	0.60
DDC	regulates	gene	0.60
DDC	colocalizes_in	gene	0.60
ALS	associated_with	gene	0.60
GBA	associated_with	gene	0.60
DDC	biomarker_for	gene	0.60
PLCG2	protects_against	gene	0.60
PINK1	associated_with	gene	0.60
APP	modulates	gene	0.60
APP	treats	gene	0.60
PTEN	activates	gene	0.60
PSEN2	associated_with	gene	0.60
PTEN	expressed_in	gene	0.60
PINK1	expressed_in	gene	0.60
RNA	regulates	gene	0.60
RNA	expressed_in	gene	0.60
PINK1	activates	gene	0.60
PSEN1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DEMENTIA WITH LEWY BODIES in their description or question text

No additional research found