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gene 3,823 words KG: LRRK2
Contents

LRRK2 — Leucine Rich Repeat Kinase 2

🧬 Gene Info
Gene SymbolLRRK2
Full NameLeucine Rich Repeat Kinase 2
Chromosome12q12
Protein TypeProtein
Subcellular LocalizationCytoplasmic vesicle, Perikaryon, Golgi apparatus membrane, Cell projection, axon, Cell projection, dendrite, Endoplasmic
Amino Acids2527 aa
PathwaysMAPK
UniProt IDSearch UniProt
GeneCardsLRRK2
Human Protein AtlasLRRK2
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/CompoundsBIIB094, BIIB122, Cigarette Smoking, DNL201, Environmental Toxicants, levodopa
Interactions6-OHDA, ACETYLCHOLINE, ACHE, Actin, AD, AKT
SciDEX HypothesesG2019S primarily raises baseline LRRK2 kinase acti
Therapeutic Window Exists Because Amplified Signal
LRRK2 Volume Sensor Hijacking Drives Metabolic Dys (+2 more)
KG Connections2616 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (38)

APOE-Dependent Autophagy Restoration
Score: 0.88Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.75Circadian-Synchronized Proteostasis Enhancement
Score: 0.74Smartphone-Detected Motor Variability Correction
Score: 0.74Senescence-Associated Myelin Lipid Remodeling
Score: 0.73TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Autophagosome Maturation Checkpoint Control
Score: 0.71Mitochondrial Transfer Pathway Enhancement
Score: 0.70Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Flotillin-1 Stabilization Compounds
Score: 0.68Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
pg 1/2Next →

Related Analyses (16)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedDoes TRPML1 enhancement cause therapeutic benefit or paradox
neurodegeneration · completedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedMicroglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archivedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (23)

Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40MLCS Quantification in Parkinson's Disease
validation · proposed · Score: 0.40AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne
validation · completed · Score: 0.40Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (5)

ABCA7 (Redirect)
redirect · KG edge: associated_withacetylcholine
general · KG edge: co_discussedABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: associated_withAKT1 Gene
gene · KG edge: activatesAging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: causes

Knowledge Graph (12 edges)

OPTN interacts_with LRRK2
CASP3 interacts_with LRRK2
AKT1 interacts_with LRRK2
CALCOCO2 interacts_with LRRK2
CGAS interacts_with LRRK2
CFTR interacts_with LRRK2
SQSTM1 interacts_with LRRK2
RPS6KB1 interacts_with LRRK2
GRB2 interacts_with LRRK2
RHEB interacts_with LRRK2

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