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mechanism 2,540 words KG: ent-gene-9f063e98
Contents

Parabacteroides goldsteinii Mitigation of Parkinsonism in LRRK2 Mice

🔬 Protein Info
Gene Symbolent-gene-9f063e98
ClassificationBacteroidales > Tannerellaceae > Parabacteroides
Metabolic profileProduces short-chain fatty acids (SCFAs) including acetate and propionate
Anti-inflammatory propertiesKnown to suppress TLR4-mediated inflammation in intestinal epithelial cells
KG Connections22 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Wikipedia

Related Hypotheses (15)

TREM2-mediated microglial tau clearance enhancement
Score: 0.62TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76APOE-TREM2 Interaction Modulation
Score: 0.74Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73Orexin-Microglia Modulation Therapy
Score: 0.71Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58TREM2-Dependent Microglial Senescence Transition
Score: 0.58

Related Analyses (27)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (22)

Stress Granule Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40Regulated Necrosis Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40Down Syndrome Alzheimer's Disease: Mechanisms and Therapeuti
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

40690364 counteracts ent-gene-9f063e98
40690364 phosphorylates ent-gene-9f063e98
38307024 phosphorylates and inactivates ent-gene-9f063e98
33177079 is recruited to ent-gene-9f063e98
33177079 recruits ent-gene-9f063e98
33177079 recruits JIP4 to lysosomes via phosphorylation of ent-gene-9f063e98
33177079 is orchestrated by ent-gene-9f063e98
32853409 phosphorylates ent-gene-9f063e98
34125248 is an endogenous substrate of ent-gene-9f063e98
38307024 phosphorylates ent-gene-9f063e98

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