Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about G2019S: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| LRRK2 | associated_with | protein | 0.95 |
| Parkinson's Disease | risk_factor_for | disease | 0.90 |
| RAB12 feedback loop | disrupts | mechanism | 0.70 |
| signal amplification | causes | mechanism | 0.70 |
| age-dependent neurodegeneration | causes | phenotype | 0.70 |
| RAB10/12 hyperphosphorylation | causes | mechanism | 0.70 |
| LRRK2 | activates | protein | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| G2019S primarily raises baseline LRRK2 kinase activity rathe | 0.790 | neurodegeneration | Do pathogenic LRRK2 mutations amplify vo |
| G2019S Acts as Lysosomal Volume-Sensing Amplifier via Enhanc | 0.730 | neurodegeneration | Do pathogenic LRRK2 mutations amplify vo |
| Rab12 may better report chronic lysosomal stress biology tha | 0.670 | neurodegeneration | Do pathogenic LRRK2 mutations amplify vo |
| LRRK2 G2019S Uncouples RAB29-Dependent Spatial Control from | 0.640 | neurodegeneration | Do pathogenic LRRK2 mutations amplify vo |
| G2019S Amplifies Lysosomal Volume-Sensing Through Membrane M | 0.560 | neurodegeneration | Do pathogenic LRRK2 mutations amplify vo |
| Dual-Mechanism Model: G2019S Increases Both Baseline AND Sig | 0.550 | neurodegeneration | Do pathogenic LRRK2 mutations amplify vo |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-24 | 5 hypotheses Top: 0.790
neurodegeneration | 2026-04-23 | 7 hypotheses Top: 0.780
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.666
neurodegeneration | 2026-04-15 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Protective or Pathogenic? Kinase activity and the neurodevelopmental origins of [PMID:41344986] | Gatto EM, Espay AJ, Espindola M, Da Prat | Parkinsonism & related disorde | 2026 | 0 |
| LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopa [PMID:41128923] | Buck SA, Malankhanova T, Strader S, Ma E | Acta neuropathologica | 2025 | 0 |
| RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome hom [PMID:39343966] | Li X, Zhu H, Huang BT, Li X, Kim H, Tan | Nature communications | 2024 | 0 |
| Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to [PMID:35012605] | Xu E, Boddu R, Abdelmotilib HA, Sokratia | Molecular neurodegeneration | 2022 | 0 |
| Exploring the focal role of LRRK2 kinase in Parkinson's disease. [PMID:35147886] | ["Kumar Sachin", "Behl Tapan", "Sehgal A | Environmental science and poll | 2022 | 0 |
| Elevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease. [PMID:35521944] | Wang S, Unnithan S, Bryant N | Mov Disord | 2022 | 0 |
| R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in [PMID:34125248] | Fan, Nirujogi, Garrido, Ruiz-Martín | Acta neuropathologica | 2022 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Rab GTPases as Physiological Substrates of LRRK2 Kinase. [PMID:31138985] | Seol W, Nam D, Son I | Exp Neurobiol | 2019 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
| Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab [PMID:29127255] | ["Fan Ying", "Howden Andrew J M", "Sarha | The Biochemical journal | 2018 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.80 · 2026-04-26
closed · Rounds: 4 · Score: 0.74 · 2026-04-24
closed · Rounds: 4 · Score: 0.85 · 2026-04-16
closed · Rounds: 4 · Score: 0.95 · 2026-04-16
Hypotheses and analyses mentioning G2019S in their description or question text