| Gene Symbol | ent-gene-9f063e98 |
| Function | LRRK2 plays important roles in synaptic function, and mutations disrupt neurotransmitter release and synaptic plasticity[@pmid-38950686] |
| Motor Symptoms | Resting tremor, bradykinesia, rigidity, and postural instability similar to idiopathic PD |
| Age of Onset | Typically later onset, around 65 years on average |
| Levodopa Response | Generally good response to dopaminergic therapy |
| Non-Motor Symptoms | Hyposmia (reduced smell) common, sleep disorders, cognitive changes variable |
| Michael J. Fox Foundation (USA) | Primary coordinating organization providing funding, infrastructure, and coordination support |
| University College London (UK) | International coordination hub for LRRK2 research, hosting the LRRK2 Cohort Consortium |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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