Contents

LRRK2 (Leucine-Rich Repeat Kinase 2) — Comprehensive Gene Review

🧬 Gene Info

Gene Symbol	LRRK2
Full Name	LRRK2 (Leucine-Rich Repeat Kinase 2)
Chromosome	12q12
Protein Type	Protein
Amino Acids	2527 aa
Pathways	MAPK
UniProt ID	Search UniProt
GeneCards	LRRK2
Human Protein Atlas	LRRK2
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	BIIB094, BIIB122, Cigarette Smoking, DNL201, Environmental Toxicants, levodopa
Interactions	6-OHDA, ACETYLCHOLINE, ACHE, Actin, AD, AKT
SciDEX Hypotheses	G2019S primarily raises baseline LRRK2 kinase acti Therapeutic Window Exists Because Amplified Signal LRRK2 Volume Sensor Hijacking Drives Metabolic Dys (+2 more)
KG Connections	2616 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING