| Gene Symbol | ent-gene-9f063e98 |
| Subcellular Localization | various cellular compartments where it influences synaptic function, protein clearance, and inflammatory responses. [@al |
| Activation loop | Contains key phosphorylation sites including Ser1292 (a major autophosphorylation site) |
| DFG motif | Asp-Phe-Gly motif essential for ATP binding |
| A-loop conformation | Kinase activity is regulated by the conformational state of the activation loop |
| ROC domain mutations (R1441C/G/H) | Impair GTP binding/hydrolysis, leading to constitutive kinase activation |
| COR domain mutations (I2020T, Y1699C) | Disrupt kinase-ROC communication |
| Kinase domain mutation (G2019S) | Directly increases catalytic activity |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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