| Gene Symbol | JAK3 |
| Full Name | Janus Kinase 3 |
| Protein Type | Receptor |
| Function | encodes a non-receptor tyrosine kinase that plays essential roles in cytokine receptor signaling, particularly in lymphoid cells. |
| Primary Expression | microglia and astrocytes, where it mediates cytokine-driven inflammatory response |
| Amino Acids | 1124 aa |
| Pathways | JAK-STAT signaling |
| Ensembl ID | ENSG00000105639 |
| GeneCards | JAK3 |
| Human Protein Atlas | JAK3 |
| Associated Diseases | Inflammation, Ms, Neuroinflammation |
| Interactions | APOPTOSIS, CYTOKINES, GBM, IRF1, JAK, JAK1 |
| KG Connections | 79 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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