gene 557 words KG: IDH1
Contents

IDH1 Gene - Isocitrate Dehydrogenase 1

🧬 Gene Info
Gene SymbolIDH1
Full NameIsocitrate Dehydrogenase 1 (NADP+)
AliasesPage for IDH1 Gene, Page for IDH1 Protein
Chromosome2q33.3
Protein TypeEnzyme
FunctionIDH1 is a NADP+-dependent enzyme localized primarily in the cytosol and peroxisomes.
Molecular Weight47 kDa
PathwaysEpigenetic
UniProt IDO75874
NCBI Gene ID3417
Ensembl IDENSG00000138449
GeneCardsIDH1
Human Protein AtlasIDH1
Associated DiseasesAD, ADH, Aging, ALI, Als, AMI
InteractionsADRA2A, ALDH1A2, APOB, ASTROCYTE, CANCER, DMSO
KG Connections368 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (9)

Noradrenergic-Tau Propagation Blockade
Score: 0.71
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
Arginine Methylation Enhancement Therapy
Score: 0.65
Nucleolar Stress Response Normalization
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65

Related Analyses (6)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (14)

IDH1 and IDH2 mutation sequencing in CNS and non-CNS tumors
exploratory · proposed · Score: 0.95
Clinical outcome analysis based on IDH mutation status
clinical · proposed · Score: 0.85
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40

See Also (7)

Astrocytes
cell · KG edge: therapeutic_target
APOB Gene
gene · KG edge: therapeutic_target
ATRX — Alpha Thalassemia/Mental Retardation Syndrome X-
gene · KG edge: associated_with
BRAF — B-Raf Proto-Oncogene, Serine/Threonine Kinase
gene · KG edge: associated_with
CALM1 — Calmodulin 1
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

IDH1 activates MTOR
IDH1 inhibits IDH2
IDH1 therapeutic_target VEGFA
IDH1 therapeutic_target MDM4
IDH1 therapeutic_target APOB
IDH1 therapeutic_target SF3B1
IDH1 therapeutic_target MET
IDH1 therapeutic_target SMARCA4
IDH1 therapeutic_target TERT
IDH1 therapeutic_target JUN

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