Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KDM4C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | KDM4C |
| Full Name | Lysine Demethylase 4C |
| Chromosome | 9p24.1 |
| Function | encodes a JmjC domain-containing histone demethylase that removes di- and trimethyl marks from histone H3 lysine 9 (H3K9me2/3) and histone H3 lysine 36 (H3K36me2/3). |
| UniProt ID | Q9H3R0 |
| Ensembl ID | ENSG00000107077 |
| OMIM | 605469 |
| GeneCards | KDM4C |
| Human Protein Atlas | KDM4C |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
KDM4C["KDM4C
Histone Demethylase"]
IDH1["IDH1
Isocitrate Dehydrogenase"]
H3K9me3["H3K9me3
Trimethyl Histone H3"]
H3K36me3["H3K36me3
Trimethyl Histone H3"]
chromatin_remodeling["Chromatin Remodeling"]
gene_expression["Neuronal Gene Expression"]
DNA_damage["DNA Damage Response"]
oxidative_stress["Oxidative Stress"]
mitochondrial_dysfunction["Mitochondrial Dysfunction"]
neuronal_apoptosis["Neuronal Apoptosis"]
protein_aggregation["Protein Aggregation"]
synaptic_dysfunction["Synaptic Dysfunction"]
neurodegeneration["Neurodegeneration"]
alzheimers["Alzheimer's Disease"]
parkinsons["Parkinson's Disease"]
IDH1 -->|"upregulates"| KDM4C
KDM4C -->|"demethylates"| H3K9me3
KDM4C -->|"demethylates"| H3K36me3
H3K9me3 -->|"regulates"| chromatin_remodeling
H3K36me3 -->|"regulates"| chromatin_remodeling
chromatin_remodeling -->|"modulates"| gene_expression
KDM4C -->|"disrupts"| DNA_damage
DNA_damage -->|"triggers"| oxidative_stress
oxidative_stress -->|"causes"| mitochondrial_dysfunction
mitochondrial_dysfunction -->|"leads to"| neuronal_apoptosis
gene_expression -->|"affects"| protein_aggregation
protein_aggregation -->|"impairs"| synaptic_dysfunction
neuronal_apoptosis -->|"contributes to"| neurodegeneration
synaptic_dysfunction -->|"contributes to"| neurodegeneration
neurodegeneration -->|"manifests as"| alzheimers
neurodegeneration -->|"manifests as"| parkinsons
style KDM4C fill:#1a3a4a,stroke:#4fc3f7
style chromatin_remodeling fill:#1a3a2a,stroke:#81c784
style gene_expression fill:#1a3a2a,stroke:#81c784
style IDH1 fill:#2a1a3a,stroke:#ce93d8
style H3K9me3 fill:#2a1a3a,stroke:#ce93d8
style H3K36me3 fill:#2a1a3a,stroke:#ce93d8
style DNA_damage fill:#3a1a1a,stroke:#ef5350
style oxidative_stress fill:#3a1a1a,stroke:#ef5350
style mitochondrial_dysfunction fill:#3a1a1a,stroke:#ef5350
style neuronal_apoptosis fill:#3a1a1a,stroke:#ef5350
style protein_aggregation fill:#3a1a1a,stroke:#ef5350
style synaptic_dysfunction fill:#3a1a1a,stroke:#ef5350
style neurodegeneration fill:#3a2a1a,stroke:#ffa726
style alzheimers fill:#3a2a1a,stroke:#ffa726
style parkinsons fill:#3a2a1a,stroke:#ffa726| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| IDH1 | upregulates | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KDM4C in their description or question text
No additional research found