gene

KDM4B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KDM4B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

0Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for KDM4B (Lysine Demethylase 4B)

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🧬 Gene Info

Gene Symbol	KDM4B
Full Name	Lysine Demethylase 4B
Chromosome	19p13.3
Function	encodes a Jumonji C (JmjC) domain-containing histone demethylase that catalyzes the removal of di- and trimethyl groups from histone H3 at lysines 9 and 36 (H3K9me2/3 and H3K36me2/3).
Amino Acids	096 aa
UniProt ID	[O94953](https://www.uniprot.org/uniprot/O94953)
Ensembl ID	ENSG00000127663
GeneCards	KDM4B
Human Protein Atlas	KDM4B
JmjN domain	The N-terminal Jumonji N domain (~80 amino acids) is required for catalytic activity and protein stability. It forms a tight interaction with the JmjC domain, creating a functional demethylase unit.
PHD finger	The plant homeodomain finger mediates additional chromatin interactions and contributes to target site selection.
Associated Diseases	neurodegeneration
KG Connections	1 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KDM4B (Lysine Demethylase 4B)

gene · 2103 words

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Pathway Diagram

graph TD
    KDM4B["KDM4B
Histone Demethylase"]
    IDH1["IDH1
Isocitrate Dehydrogenase"]
    H3K9me3["H3K9me3
Repressive Chromatin Mark"]
    H3K36me3["H3K36me3
Active Chromatin Mark"]
    Alpha_KG["alpha-Ketoglutarate
Cofactor"]
    Chromatin_Open["Open Chromatin
State"]
    Gene_Expression["Altered Gene
Expression"]
    Neuronal_Death["Neuronal Cell
Death"]
    Protein_Aggregation["Protein
Aggregation"]
    Synaptic_Dysfunction["Synaptic
Dysfunction"]
    Alzheimers["Alzheimer's
Disease"]
    Parkinsons["Parkinson's
Disease"]
    Huntingtons["Huntington's
Disease"]
    Oxidative_Stress["Oxidative
Stress"]
    DNA_Damage["DNA Damage
Response"]
    Neuroinflammation["Neuroinflammation"]

    IDH1 -->|"upregulates"| KDM4B
    IDH1 -->|"produces"| Alpha_KG
    Alpha_KG -->|"cofactor for"| KDM4B
    KDM4B -->|"demethylates"| H3K9me3
    KDM4B -->|"demethylates"| H3K36me3
    H3K9me3 -->|"removal creates"| Chromatin_Open
    H3K36me3 -->|"removal alters"| Chromatin_Open
    Chromatin_Open -->|"leads to"| Gene_Expression
    Gene_Expression -->|"contributes to"| Neuronal_Death
    Gene_Expression -->|"promotes"| Protein_Aggregation
    Neuronal_Death -->|"characteristic of"| Alzheimers
    Neuronal_Death -->|"characteristic of"| Parkinsons
    Protein_Aggregation -->|"leads to"| Synaptic_Dysfunction
    Synaptic_Dysfunction -->|"contributes to"| Huntingtons
    KDM4B -->|"dysregulates"| DNA_Damage
    DNA_Damage -->|"triggers"| Oxidative_Stress
    Oxidative_Stress -->|"promotes"| Neuroinflammation

    style KDM4B fill:#1a3a4a,stroke:#4fc3f7
    style Alpha_KG fill:#1a3a2a,stroke:#81c784
    style IDH1 fill:#2a1a3a,stroke:#ce93d8
    style Chromatin_Open fill:#2a1a3a,stroke:#ce93d8
    style Gene_Expression fill:#2a1a3a,stroke:#ce93d8
    style Neuronal_Death fill:#3a1a1a,stroke:#ef5350
    style Protein_Aggregation fill:#3a1a1a,stroke:#ef5350
    style Synaptic_Dysfunction fill:#3a1a1a,stroke:#ef5350
    style Oxidative_Stress fill:#3a1a1a,stroke:#ef5350
    style DNA_Damage fill:#3a1a1a,stroke:#ef5350
    style Neuroinflammation fill:#3a1a1a,stroke:#ef5350
    style Alzheimers fill:#3a2a1a,stroke:#ffa726
    style Parkinsons fill:#3a2a1a,stroke:#ffa726
    style Huntingtons fill:#3a2a1a,stroke:#ffa726

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
IDH1	upregulates	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KDM4B in their description or question text

No additional research found