gene 3,036 words KG: HTT
Contents

HTT (Huntingtin)

🧬 Gene Info
Gene SymbolHTT
Full NameHuntingtin
Chromosome4p16.3.
Functionis a large, multifunctional protein encoded by the HTT gene on chromosome 4p16.
Subcellular Localizationand protein interactions
Molecular Weight350 kDa
Amino Acids144 aa
Exons67
PathwaysAutophagy, Dna Repair
UniProt IDP42857
NCBI Gene ID3064
Ensembl IDENSG00000197393
OMIM143100
GeneCardsHTT
Human Protein AtlasHTT
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compoundsdimethyl fumarate, rapamycin, RAPAMYCIN
InteractionsABP, ACHE, Actin, AD, AKT, ALS
KG Connections805 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (23)

Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.61
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
APOE-Dependent Autophagy Restoration
Score: 0.85
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82

Related Analyses (7)

CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completed
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

Related Experiments (3)

Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · proposed · Score: 0.40
Mutant Huntingtin (mHTT) Clearance Mechanisms — Therapeutic
validation · proposed · Score: 0.40
s:** - Temporal analysis showing mitochondrial defects prece
falsification · proposed · Score: 0.40

See Also (5)

ACTB Gene
gene · KG edge: associated_with
Gene Page: ALS4 (SENATAXIN)
gene · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with

Knowledge Graph (12 edges)

HTT regulates calcium
HTT regulates CA2
HUNTINGTON associated_with HTT
ACTB associated_with HTT
GABARAP associated_with HTT
ULK1 associated_with HTT
WIPI2 associated_with HTT
LC3 associated_with HTT
BECN1 associated_with HTT
HTT associated_with ATG7

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