protein 3,473 words KG: HTTPROTEIN
Contents

Huntingtin Protein (HTT)

🔬 Protein Info
Gene SymbolHTT
Full NameHuntingtin
Chromosome4p16.3.
Functionis a large, multifunctional protein encoded by the HTT gene on chromosome 4p16.
Molecular Weight350 kDa
Amino Acids144 aa
Exons67
PathwaysAutophagy, Dna Repair
UniProt IDP42857
NCBI Gene ID3064
Ensembl IDENSG00000197393
OMIM143100
GeneCardsHTT
Human Protein AtlasHTT
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compoundsdimethyl fumarate, rapamycin, RAPAMYCIN
InteractionsABP, ACHE, Actin, AD, AKT, ALS
KG Connections806 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (9)

Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.61
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62

Related Analyses (9)

CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (2)

Neurodegeneration
disease · KG edge: implicated_in
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: associated_with

Knowledge Graph (3 edges)

HTTPROTEIN associated_with TREM2
HTTPROTEIN expressed_in TREM2
HTTPROTEIN protects_against TREM2

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