concept

CD206

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD206: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

0Analyses

49Outgoing

11Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CD206
Key Genes/Proteins	ACSL4, AMPK, ARG1, ASC, CD14, CD163
Related Diseases	Alzheimer's disease, cancer
Related Pathways	ferroptosis

Pathway Diagram

graph TD
    CD206[CD206]
    CD206 -.biomarker for.-> macrophage_polarization[macrophage polarization]
    CD206 -->|activates| neuroinflammation[neuroinflammation]
    CD206 -.biomarker for.-> Sarcopenia[Sarcopenia]
    CD206 -.biomarker for.-> M2_anti_inflammatory_phenotype[M2 anti-inflammatory phenotype]
    CD206 -->|regulates| Macrophage_Subsets[Macrophage Subsets]
    CD206 -->|activates| NOS2[NOS2]
    CD206 -->|activates| TNF[TNF]
    CD206 -->|activates| CD36[CD36]
    CD206 -->|activates| CD68[CD68]
    CD206 -->|regulates| JAK2[JAK2]
    CD22_Blockade[CD22 Blockade] -->|upregulates| CD206
    PPAR__antagonist[PPARγ antagonist] -->|activates| CD206
    ARG1[ARG1] -->|activates| CD206
    CD163[CD163] -->|activates| CD206
    ASC[ASC] -.biomarker for.-> CD206
    ACSL4[ACSL4] -.biomarker for.-> CD206
    AMPK[AMPK] -->|activates| CD206
    benchmark_ot_ad_answer_key_CD2[benchmark_ot_ad_answer_key:CD206] -->|data_in| CD206

Outgoing (49)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CD206	data_in	dataset_row	0.00
macrophage polarization	biomarker_for	process	0.85
neuroinflammation	activates	disease	0.80
Macrophage Subsets	associated_with	cell_type	0.75
Sarcopenia	biomarker_for	disease	0.75
M2 anti-inflammatory phenotype	biomarker_for	cell_type	0.70
TNF	activates	gene	0.60
CD36	activates	gene	0.60
CD68	activates	gene	0.60
JAK2	regulates	gene	0.60
STAT3	regulates	gene	0.60
CD86	activates	gene	0.60
NLRP3	activates	gene	0.60
TLR4	activates	gene	0.60
CD80	activates	gene	0.60
CD38	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
Macrophage Subsets	regulates	cell_type	0.60
NOS2	activates	gene	0.60
JAK-STAT signaling	participates_in	pathway	0.60
TYROBP	expressed_in	gene	0.60
CD86	expressed_in	gene	0.60
NLRP3	expressed_in	gene	0.60
PI3K	inhibits	gene	0.60
CD36	biomarker_for	gene	0.60
GPX4	biomarker_for	gene	0.60
HO1	biomarker_for	gene	0.60
IL6	biomarker_for	gene	0.60
LRP1	biomarker_for	gene	0.60
SLC40A1	biomarker_for	gene	0.60
SLC7A11	biomarker_for	gene	0.60
TNF	biomarker_for	gene	0.60
ferroptosis	participates_in	pathway	0.60
CD68	expressed_in	gene	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
GSH	biomarker_for	gene	0.60
CD68	associated_with	gene	0.60
cancer	associated_with	disease	0.60
neurodegeneration	activates	disease	0.60
NF-kB signaling	participates_in	pathway	0.60
Alzheimer's disease	biomarker_for	disease	0.60
METTL3	activates	gene	0.60
YTHDF1	activates	gene	0.60
TGF	activates	gene	0.60
TGF-beta signaling	participates_in	pathway	0.60
MAPK	activates	gene	0.60
MAPK signaling	participates_in	pathway	0.60
macrophages	expressed_in	cell_type	0.55
microglia	expressed_in	cell_type	0.55

Incoming (11)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CD206	data_in	dataset_row	0.00
CD22 Blockade	upregulates	drug	0.85
PPARγ antagonist	activates	drug	0.70
ARG1	activates	gene	0.60
CD163	activates	gene	0.60
CD14	associated_with	gene	0.60
CD163	associated_with	gene	0.60
ASC	biomarker_for	gene	0.60
ACSL4	biomarker_for	gene	0.60
CD163	biomarker_for	gene	0.60
AMPK	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CD206 in their description or question text

No additional research found