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Methodology challenge: notebook 'Astrocyte reactivity subtypes in neurodegenerat

active · Rounds: 4 · Score: 0.64 · 2026-04-28

Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia

active · Rounds: 4 · Score: 0.64 · 2026-04-28

Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia

active · Rounds: 4 · Score: 0.64 · 2026-04-28

Soluble PDGFRβ as a Peripheral Indicator of Pericyte-Mediated Blood-Brain Barrie

Score: 0.705 · unknown disease · 2026-04-26

Pericyte loss in Alzheimer's disease leads to proteolytic shedding of PDGFRβ into circulation, providing a blood-accessi

Pericyte-targeted senolysis or senomorphic therapy will benefit only an early bi

Score: 0.700 · neurodegeneration · 2026-04-25

Therapeutic benefit from pericyte-directed senescence interventions depends on stage. If BBB leak and dysfunction occur

Pericyte Contractility Reset via Selective PDGFR-β Agonism

Score: 0.684 · neurodegeneration · 2026-04-02

## Mechanistic Overview Pericyte Contractility Reset via Selective PDGFR-β Agonism starts from the claim that modulating

Bacterial Tyramine–Induced DOPAL Accumulation in Enteric Neurons

Score: 0.680 · neurodegeneration · 2026-04-22

## **Molecular Mechanism and Rationale** The proposed mechanism centers on a complex interplay between gut microbiota,

Pericyte-First Sequential Biomarker Cascade — Soluble PDGFR-β as Sentinel Event

Score: 0.662 · unknown disease · 2026-04-26

CSF soluble PDGFR-β shedding from pericytes as the earliest detectable molecular event in AD, preceding amyloid/tau path

Radiation drives pericyte senescence through lysosome acidification failure and

Score: 0.652 · neurodegeneration · 2026-04-25

Autophagosomes still form after irradiation, but damaged lysosomes cannot clear cargo, sustaining ROS and SASP output.

Mitochondrial ATP/ADP Carrier Activity as Bioenergetic Recovery Metric

Score: 0.642 · translational neuroscience · 2026-04-16

## **Molecular Mechanism and Rationale** The adenine nucleotide translocator (ANT), encoded by the SLC25A4 gene and als

Glycine-Rich Domain Competitive Inhibition

Score: 0.640 · neurodegeneration · 2026-04-02

## Mechanistic Overview Glycine-Rich Domain Competitive Inhibition starts from the claim that modulating TARDBP within t

Amyloid-beta induces secondary pericyte senescence after contractile and oxidati

Score: 0.640 · neurodegeneration · 2026-04-25

Soluble Aβ oligomers trigger endothelin-1 and ROS-dependent pericyte contractile stress, and repeated exposure converts

Enteric Nervous System Dysfunction as Self-Reinforcing Pathological Loop

Score: 0.630 · neurodegeneration · 2026-04-26

PD patients exhibit dual ENS pathology: α-synuclein aggregation within enteric neurons and progressive loss of cholinerg

Pericyte senescence is sufficient to weaken the BBB even without classic amyloid

Score: 0.630 · neurodegeneration · 2026-04-25

Selective induction of a senescence program in adult pericytes is sufficient to impair barrier-supportive trophic signal

Steric Occlusion of G3BP1 Oligomerization Interface

Score: 0.630 · neurodegeneration · 2026-04-21

**Molecular Mechanism and Rationale** The hypothesis centers on the precise regulation of G3BP1 (Ras GTPase-activating

APOE4-microglial complement signaling causes cholinergic-enriched synaptic vulne

Score: 0.630 · neurodegeneration · 2026-04-25

APOE4 may bias microglia toward complement-mediated pruning that disproportionately strips vulnerable long-range choline

Circulating Soluble PDGFRβ Reflects Pericyte Loss and Precedes Cognitive Decline

Score: 0.625 · unknown disease · 2026-04-26

Soluble PDGFRβ (sPDGFRβ) is released into the bloodstream upon pericyte damage, serving as a peripheral indicator of blo