gene

GASDERMIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GASDERMIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

678Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	GSDM family
Full Name	Gasdermin family
Aliases	GSDMA, GSDMB, GSDMC, GSDMD, GSDME
Function	Pore-forming proteins executing pyroptosis. GSDMD is cleaved by inflammatory caspases to form membrane pores.
Primary Expression	Macrophages, monocytes, microglia, neurons
Gene Type	Protein-coding gene family
Pathways	Pyroptosis, Inflammasome signaling, NLRP3 pathway
Associated Diseases	Als, Alzheimer, Infection, Inflammation, Ms
Interactions	Actin, AD, AIM2, ALS, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	676 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    GASDERMIN["GASDERMIN"] -.->|"inhibits"| Inflammation["Inflammation"]
    GASDERMIN["GASDERMIN"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
    GASDERMIN["GASDERMIN"] -->|"associated"| Inflammation_1["Inflammation"]
    GASDERMIN["GASDERMIN"] -->|"activates"| Stroke["Stroke"]
    GASDERMIN["GASDERMIN"] -->|"activates"| Inflammation_2["Inflammation"]
    GASDERMIN["GASDERMIN"] -->|"associated"| Infection["Infection"]
    CANCER["CANCER"] -.->|"inhibits"| GASDERMIN["GASDERMIN"]
    CELL_DEATH["CELL DEATH"] -->|"activates"| GASDERMIN["GASDERMIN"]
    CELL_DEATH_3["CELL DEATH"] -->|"causes"| GASDERMIN["GASDERMIN"]
    APOPTOSIS["APOPTOSIS"] -->|"degrades"| GASDERMIN["GASDERMIN"]
    style GASDERMIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (423)

Target	Relation	Type	Str
Lysosome Permeabilization	mediates	process	0.90
RIPK1	interacts_with	gene	0.70
HIF1A	activates	gene	0.70
GPX4	biomarker_for	gene	0.70
GPX4	activates	gene	0.70
STING	activates	gene	0.70
TNF	activates	gene	0.70
SQSTM1	activates	gene	0.70
NECROPTOSIS	mediates	pathway	0.70
RAGE	activates	gene	0.70
TLR4	expresses	gene	0.70
NECROPTOSIS	interacts_with	pathway	0.70
NLRP3	mediates	gene	0.70
NEURONS	activates	cell_type	0.70
MICROGLIA	causes	cell_type	0.70
NLRP3	biomarker_for	gene	0.70
ULK1	activates	gene	0.70
NFKB	activates	gene	0.70
TFEB	activates	gene	0.70
VEGF	activates	gene	0.70
XIAP	activates	gene	0.70
NEURONS	expresses	cell_type	0.70
GFAP	biomarker_for	gene	0.70
Melanoma	activates	disease	0.65
Autoimmune	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Sepsis	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Aging	activates	disease	0.65
Inflammation	regulates	disease	0.65
Cancer	regulates	disease	0.65
Infection	activates	disease	0.65
Tumor	activates	disease	0.65
Als	associated_with	disease	0.65
Tumor	regulates	disease	0.65
Stroke	activates	disease	0.65
Inflammation	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Infection	associated_with	disease	0.65
Inflammation	inhibits	disease	0.65
Infection	regulates	disease	0.65
Als	regulates	disease	0.65
Cancer	activates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Sepsis	activates	disease	0.65

Incoming (255)

Source	Relation	Type	Str
BHB	inhibits	compound	0.80
BDNF	biomarker_for	gene	0.70
ENDOTHELIAL	inhibits	cell_type	0.70
CGAS	activates	gene	0.70
ATG5	activates	gene	0.70
CREB	biomarker_for	gene	0.70
CXCL10	activates	gene	0.70
DBH	activates	gene	0.70
BECN1	activates	gene	0.70
BDNF	activates	gene	0.70
CREB	activates	gene	0.70
ENDOTHELIAL	activates	cell_type	0.70
AMPK	activates	gene	0.70
ROS	regulates	gene	0.60
STROKE	activates	gene	0.60
MICROGLIA	activates	gene	0.60
BRAIN INJURY	activates	gene	0.60
GENES	activates	gene	0.60
STING	activates	gene	0.60
GSDMD	associated_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
SKA2	regulates	gene	0.60
ASC	therapeutic_target	gene	0.60
IL-18	therapeutic_target	gene	0.60
NEURON	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
TAU	activates	gene	0.60
IL-18	activates	gene	0.60
RNA	activates	gene	0.60
APOPTOSIS	expresses	pathway	0.60
AD	degrades	gene	0.60
AD	activates	gene	0.60
APOPTOSIS	causes	pathway	0.60
AΒ	activates	gene	0.60
AΒ	regulates	gene	0.60
FERROPTOSIS	inhibits	pathway	0.60
CANCER	inhibits	disease	0.60
INFLAMMATION	associated_with	gene	0.60
NLRP3	activates	gene	0.60
PYROPTOSIS	associated_with	gene	0.60
GENES	regulates	gene	0.60
CANCER	therapeutic_target	gene	0.60
ERK	activates	gene	0.60
ROS	activates	gene	0.60
AND	inhibits	gene	0.60
NF-ΚB	inhibits	gene	0.60
MYD88	inhibits	gene	0.60
TRAF6	inhibits	gene	0.60
FERROPTOSIS	biomarker_for	pathway	0.60
INFLAMMATION	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GASDERMIN in their description or question text

No additional research found