Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GLUTAMATE SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | GLUTAMATE SIGNALING |
Knowledge base pages for this entity
graph TD
GLUTAMATE_SIGNALING["GLUTAMATE SIGNALING"]
Als["Als"] -->|"activates"| GLUTAMATE_SIGNALING
FERROPTOSIS["FERROPTOSIS"] -->|"activates"| GLUTAMATE_SIGNALING
NEURODEGENERATION["NEURODEGENERATION"] -->|"target for"| GLUTAMATE_SIGNALING
Neurodegeneration["Neurodegeneration"] -->|"target for"| GLUTAMATE_SIGNALING
GPX4["GPX4"] -->|"activates"| GLUTAMATE_SIGNALING
GENES["GENES"] -->|"activates"| GLUTAMATE_SIGNALING
INFLAMMATION["INFLAMMATION"] -->|"regulates"| GLUTAMATE_SIGNALING| Target | Relation | Type | Str |
|---|---|---|---|
| Temporal Lobe Epilepsy | involved_in | disease | 0.95 |
| hippocampus | active_in | brain_region | 0.90 |
| neurons | active_in | cell_type | 0.90 |
| neural stem cells | active_in | cell_type | 0.70 |
| astrocytes | active_in | cell_type | 0.70 |
| unfolded protein response | crosstalk_with | pathway | 0.70 |
| blood-brain barrier | active_in | brain_region | 0.70 |
| synaptic plasticity | crosstalk_with | pathway | 0.70 |
| cortex | active_in | brain_region | 0.70 |
| pyroptosis | crosstalk_with | pathway | 0.60 |
| hypothalamus | active_in | brain_region | 0.60 |
| endothelial cells | active_in | cell_type | 0.60 |
| necroptosis | crosstalk_with | pathway | 0.60 |
| thalamus | active_in | brain_region | 0.60 |
| oligodendrocytes | active_in | cell_type | 0.60 |
| macrophages | active_in | cell_type | 0.60 |
| white matter | active_in | brain_region | 0.60 |
| spinal cord | active_in | brain_region | 0.60 |
| protein misfolding | mediates | process | 0.60 |
| interneurons | active_in | cell_type | 0.60 |
| B cells | active_in | cell_type | 0.60 |
| microglia | active_in | cell_type | 0.60 |
| GABAergic neurons | active_in | cell_type | 0.60 |
| Neuron | encodes | cell_type | 0.50 |
| Interneuron | encodes | cell_type | 0.50 |
| Interneuron | regulates | cell_type | 0.50 |
| Neuron | activates | cell_type | 0.50 |
| Stem Cell | activates | cell_type | 0.50 |
| Neuron | regulates | cell_type | 0.50 |
| DOPAMINE | regulates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's disease | involves | disease | 0.90 |
| neurodegeneration | involves | disease | 0.90 |
| NMDA receptor | activates | receptor | 0.90 |
| neurons | active_in | cell_type | 0.85 |
| NMDA | participates_in | gene | 0.85 |
| PSD-95 | participates_in | gene | 0.85 |
| memantine | modulates | compound | 0.80 |
| glutamate receptor | activates | receptor | 0.80 |
| epilepsy | involves | disease | 0.80 |
| neuroinflammation | involves | disease | 0.80 |
| APP | participates_in | gene | 0.80 |
| ALS | involves | disease | 0.80 |
| ALS | participates_in | gene | 0.80 |
| Als | activates | disease | 0.80 |
| astrocytes | active_in | cell_type | 0.75 |
| spinal muscular atrophy | involves | disease | 0.70 |
| FERROPTOSIS | activates | gene | 0.70 |
| APC | participates_in | gene | 0.70 |
| NEURODEGENERATION | therapeutic_target | gene | 0.70 |
| Neurodegeneration | therapeutic_target | disease | 0.70 |
| AMPA receptor | activates | receptor | 0.70 |
| Neurodegeneration | activates | disease | 0.70 |
| NEURODEGENERATION | activates | gene | 0.70 |
| PSD95 | participates_in | gene | 0.65 |
| STIM1 | participates_in | gene | 0.60 |
| C9ORF72 | participates_in | gene | 0.60 |
| BIN1 | participates_in | gene | 0.60 |
| PTK2B | participates_in | gene | 0.60 |
| PICALM | participates_in | gene | 0.60 |
| DLG2 | participates_in | gene | 0.60 |
| NMDAR | participates_in | gene | 0.60 |
| donepezil | modulates | compound | 0.60 |
| nicotinic receptor | activates | receptor | 0.60 |
| statins | modulates | compound | 0.60 |
| RAGE | participates_in | gene | 0.60 |
| TH | participates_in | gene | 0.60 |
| NPY | participates_in | gene | 0.60 |
| TNF | participates_in | gene | 0.60 |
| GPX4 | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| INFLAMMATION | regulates | gene | 0.60 |
| NEURODEGENERATION | regulates | gene | 0.60 |
| STIM1 | activates | gene | 0.60 |
| STING | regulates | gene | 0.60 |
| TAU | activates | gene | 0.60 |
| ELAVL4 | activates | gene | 0.60 |
| MAPT | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| PIKFYVE | activates | gene | 0.60 |
| NEURON | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GLUTAMATE SIGNALING in their description or question text
No additional research found