gene

GLI2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLI2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

0Analyses

20Outgoing

10Incoming

0Experiments

0Debates

Summary

GLI2 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Cancer, Colorectal Cancer, Tumor. Connected to 11 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GLI2
Full Name	GLI Family Zinc Finger 2
Chromosome	2q14.2
Protein Type	Transcription Factor
Function	encodes a 1586 amino acid zinc finger transcription factor that functions as the primary transcriptional activator of the Hedgehog (Hh) signaling pathway.
Primary Expression	the ventral neural tube floor plate, where it is essential for specification of ventral cell fates including dopaminergic progenitors of the midbrain
Amino Acids	1586 aa
Exons	13
Pathways	Apoptosis, Hedgehog
Ensembl ID	ENSG00000074047
GeneCards	GLI2
Human Protein Atlas	GLI2
Associated Diseases	neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	APOPTOSIS, BCL2, CANCER, FKBP5, GAPDH, GFAP
KG Connections	30 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GLI2

gene · 1231 words

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Pathway Diagram

graph TD
    GLI2["GLI2"]
    Colorectal_Cancer{"Colorectal Cancer"}
    GLI2 -->|"activates"| Colorectal_Cancer
    Cancer{"Cancer"}
    GLI2 -->|"activates"| Cancer
    Tumor{"Tumor"}
    GLI2 -->|"activates"| Tumor
    Apoptosis(["Apoptosis"])
    GLI2 -->|"activates"| Apoptosis
    Hedgehog(["Hedgehog"])
    GLI2 -->|"activates"| Hedgehog
    GLI1["GLI1"]
    GLI1 -->|"activates"| GLI2
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| GLI2
    BCL2["BCL2"]
    BCL2 -->|"activates"| GLI2
    CANCER["CANCER"]
    CANCER -->|"activates"| GLI2
    SMO["SMO"]
    SMO -->|"activates"| GLI2
    neurodegeneration["neurodegeneration"]
    GLI2 -->|"implicated_in"| neurodegeneration

Outgoing (20)

Target	Relation	Type	Str
Colorectal Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Apoptosis	activates	pathway	0.60
Hedgehog	activates	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
LC3B	activates	gene	0.60
PS1	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
IL6	activates	gene	0.60
LAMP1	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
MTOR	activates	gene	0.60
PPARA	activates	gene	0.60
PSEN1	activates	gene	0.60
SQSTM1	activates	gene	0.60
SYP	activates	gene	0.60
TFEB	activates	gene	0.60
TNF	activates	gene	0.60
microglia	expressed_in	cell_type	0.55

Incoming (10)

Source	Relation	Type	Str
GLI	activates	gene	0.60
rapamycin	targets	drug	0.60
GLI1	activates	gene	0.60
BCL2	activates	gene	0.60
SMO	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
CANCER	activates	gene	0.60
FKBP5	activates	gene	0.60
GAPDH	activates	gene	0.60
GFAP	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GLI2 in their description or question text

No additional research found