Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GLI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GLI1, GLI2, GLI3 zinc finger transcription factors in Hedgehog signaling and neurodegenerative diseases
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| Gene Symbol | GLI |
| Function | The GLI gene family (GLI1, GLI2, GLI3) encodes C2H2-type zinc finger transcription factors that serve as the primary effectors of the Hedgehog (Hh) signaling pathway. |
| Exons | 12 |
| GeneCards | GLI |
| Human Protein Atlas | GLI |
| Associated Diseases | ALS |
| Known Drugs/Compounds | metformin, rapamycin |
| Interactions | ATG, ATG7, BNIP3, BRD4, FKBP5, GAPDH |
| KG Connections | 32 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GLI["GLI"] -->|"associated_with"| ALS["ALS"]
GLI["GLI"] -->|"co_expressed_with"| GLI1["GLI1"]
GLI["GLI"] -->|"co_expressed_with"| MYC["MYC"]
BRD4["BRD4"] -->|"co_expressed_with"| GLI["GLI"]
BECN1["BECN1"] -->|"co_expressed_with"| GLI["GLI"]
BNIP3["BNIP3"] -->|"co_expressed_with"| GLI["GLI"]
style GLI fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| GLI1 | activates | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| TFEB | activates | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| SYP | activates | gene | 0.60 |
| PSEN1 | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| ALS | associated_with | disease | 0.60 |
| GLI2 | activates | gene | 0.60 |
| IL6 | activates | gene | 0.60 |
| LAMP1 | activates | gene | 0.60 |
| LC3B | activates | gene | 0.60 |
| MAP1LC3B | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| PPARA | activates | gene | 0.60 |
| PS1 | activates | gene | 0.60 |
| microglia | expressed_in | cell_type | 0.55 |
| MYC | co_expressed_with | gene | 0.50 |
| GLI1 | co_expressed_with | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FKBP5 | activates | gene | 0.60 |
| GAPDH | activates | gene | 0.60 |
| GFAP | activates | gene | 0.60 |
| rapamycin | targets | drug | 0.60 |
| metformin | targets | drug | 0.60 |
| ATG | activates | gene | 0.60 |
| ATG7 | activates | gene | 0.60 |
| BNIP3 | activates | gene | 0.60 |
| BRD4 | inhibits | gene | 0.60 |
| BRD4 | co_expressed_with | gene | 0.50 |
| BECN1 | co_expressed_with | gene | 0.50 |
| BNIP3 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | in_progress | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| E2F coordination of G2/M transcriptional program | exploratory | 0.750 | 0.00 | endocycling mammalian cells | proposed | N/A | |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.200 | 0.00 | Mouse (5xFAD/TREM2-/-) | in_progress | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214] | Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia | J Inflamm Res | 2022 | 1 |
| TREM2, microglia, and Alzheimer's disease. [PMID:33516818] | Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang | Mech Ageing Dev | 2021 | 1 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. [PMID:28802038] | Ulland TK, Song WM, Huang SC, Ulrich JD, | Cell | 2017 | 1 |
| The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663] | Krasemann S, Madore C, Cialic R, Baufeld | Immunity | 2017 | 1 |
| Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and T [PMID:41833042] | ["Lyu G", "Li D"] | CNS & neurological disorders d | 2026 | 0 |
| Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuro [PMID:41858793] | ["Wang R", "Feng Y", "Zhou Z", "Jiang J" | Frontiers in aging neuroscienc | 2026 | 0 |
| Human CSF proteogenomics links genetic variation to neurodegenerative disease pr [PMID:41757182] | ["Puerta R", "Garc\u00eda-Gonz\u00e1lez | medRxiv : the preprint server | 2026 | 0 |
| PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907] | Tsai AP, Martin AK, Mi A, Yeh AE, Ramire | Molecular neurodegeneration | 2026 | 0 |
| PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907] | Tsai AP, Martin AK, Mi A, Yeh AE, Ramire | Mol Neurodegener | 2026 | 0 |
| TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604] | Yang HC, Deng YS, Zhang J, Zhang T, Song | J Alzheimers Dis | 2026 | 0 |
| Investigating the Potential of Gene Editing Technologies in Enhancing Stem Cell [PMID:41926312] | ["Mehrabadi S"] | Current aging science | 2026 | 0 |
| TREM2 in neurodegeneration and diseases. [PMID:41792456] | ["Abdulkhaliq A", "Alasiri G", "Kim B", | Molecular psychiatry | 2026 | 0 |
| Berbamine hydrochloride as a brain penetrant galectin 3 inhibitor in a model of [PMID:41772384] | ["Siew J", "Lee C", "Chen H", "Lin H", " | Brain : a journal of neurology | 2026 | 0 |
| The microglial TREM2 receptor programs hippocampal development in a mouse model [PMID:41887542] | Ahmed S, Bowers C, Munoz-Martin J, Jamwa | Brain, behavior, and immunity | 2026 | 0 |
| Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842] | Alhusaini M, Mussa BM, Ilce BY, Alhaj H, | Frontiers in aging neuroscienc | 2026 | 0 |
| Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial n [PMID:41881962] | Baek S, Jang J, Yeo S, Jung HJ, Choe Y | Signal transduction and target | 2026 | 0 |
| Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ4 [PMID:41770935] | ["Konstantoulea K", "Ramakers M", "Borri | Proceedings of the National Ac | 2026 | 0 |
| Microglia, Trem2, and Neurodegeneration. [PMID:38769824] | Shi Q, Gutierrez RA, Bhat MA | Neuroscientist | 2025 | 0 |
| Microglia, Trem2, and Neurodegeneration. [PMID:38769824] | Shi Q, Gutierrez RA, Bhat MA | The Neuroscientist : a review | 2025 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GLI in their description or question text
Score: 0.907 · neurodegeneration · 2026-04-12
## Mechanistic Overview TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration starts from the claim that mo
Score: 0.898 · neurodegeneration · 2026-04-16
## Mechanistic Overview CSF1R Inhibition-Mediated Microglial Replacement as a State Transition Reset starts from the cla
Score: 0.895 · neurodegeneration · 2026-04-12
## Mechanistic Overview SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senescence starts from the claim that modu
Score: 0.892 · neurodegeneration · 2026-04-07
## Mechanistic Overview TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration starts from the claim that mod
Score: 0.887 · neurodegeneration · 2026-04-14
## Mechanistic Overview H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from Synapse Pruning to Amyloid Clearance
Score: 0.880 · neurodegeneration · 2026-04-07
## **Molecular Mechanism and Rationale** The triggering receptor expressed on myeloid cells 2 (TREM2) serves as a criti
Score: 0.879 · neurodegeneration · 2026-04-16
## Mechanistic Overview Optimized Temporal Window for Metabolic Boosting Therapy Determines Success of Microglial State
Score: 0.875 · neurodegeneration · 2026-04-07
**Molecular Mechanism and Rationale** The TREM2-mediated astrocyte-microglia cross-talk mechanism represents a complex
Score: 0.869 · neurodegeneration · 2026-04-07
## Mechanistic Overview TREM2-Mediated Cholesterol Dysregulation in Microglial Senescence starts from the claim that mod
Score: 0.847 · neurodegeneration · 2026-04-17
## Mechanistic Overview Microglial Senescence Prevention via TREM2/SASP Axis starts from the claim that modulating not y
Score: 0.847 · Alzheimer's Disease · 2026-04-02
## Mechanistic Overview ACSL4-Driven Ferroptotic Priming in Disease-Associated Microglia starts from the claim that modu
Score: 0.843 · neurodegeneration · 2026-04-16
## Mechanistic Overview miR-155/Interferon-gamma Feedback Loop as a Reversible Molecular Switch for Protective Microglia
Score: 0.824 · neurodegeneration · 2026-04-05
## Mechanistic Overview Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 Proteinopathy Neuroinflammation in
Score: 0.812 · neuroscience · 2026-04-12
## Mechanistic Overview TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance starts from the claim
Score: 0.808 · neurodegeneration · 2026-04-16
## Mechanistic Overview CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion starts from the claim that modulating