gene

PPP1CA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP1CA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

0Analyses

12Outgoing

9Incoming

0Experiments

0Debates

Summary

PPP1CA is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Cancer, Carcinoma, Ms. Connected to 11 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	PPP1CA
Aliases	Protein Phosphatase 1 Alpha
Chromosome	11q13.4
Protein Type	Gene
Function	[@sachidanandam2017]
Primary Expression	neurons and glia
Subcellular Localization	**: Predominantly cytoplasmic, with nuclear localization in some cell types
Molecular Weight	37 kDa
Amino Acids	330 aa
Exons	7
Pathways	Akt, Mtor
GeneCards	PPP1CA
Human Protein Atlas	PPP1CA
Associated Diseases	neurodegeneration
Interactions	AKT, AMPK, CANCER, LUZP1, MTOR, VHL
KG Connections	20 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ppp1ca

gene · 1165 words

→

PPP1CA Protein (Protein Phosphatase 1 Alpha)

protein · 520 words

→

Pathway Diagram

graph TD
    PPP1CA["PPP1CA"]
    Carcinoma{"Carcinoma"}
    PPP1CA -->|"activates"| Carcinoma
    Ms{"Ms"}
    PPP1CA -->|"activates"| Ms
    Cancer{"Cancer"}
    PPP1CA -->|"activates"| Cancer
    Tumor{"Tumor"}
    PPP1CA -->|"activates"| Tumor
    AKT["AKT"]
    PPP1CA -->|"activates"| AKT
    CANCER["CANCER"]
    PPP1CA -->|"activates"| CANCER
    Akt(["Akt"])
    PPP1CA -->|"activates"| Akt
    Mtor(["Mtor"])
    PPP1CA -->|"activates"| Mtor
    neurodegeneration["neurodegeneration"]
    PPP1CA -->|"implicated in"| neurodegeneration
    VHL["VHL"]
    VHL -->|"activates"| PPP1CA
    MTOR["MTOR"]
    MTOR -->|"activates"| PPP1CA
    style PPP1CA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

Target	Relation	Type	Str
AMPK	activates	protein	0.85
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Carcinoma	activates	disease	0.65
Ms	activates	disease	0.65
Mtor	activates	pathway	0.60
CANCER	activates	gene	0.60
Akt	activates	pathway	0.60
AKT	activates	gene	0.60
VPS29	targets	gene	0.60
VPS35	targets	gene	0.60
YBX1	targets	gene	0.60

Incoming (9)

Source	Relation	Type	Str
LUZP1	interacts_with	protein	0.88
Spnphilin	interacts_with	protein	0.80
BECN1	targets	gene	0.60
CYP27B1	targets	gene	0.60
GCLC	targets	gene	0.60
PCBP2	targets	gene	0.60
PEX13	targets	gene	0.60
VHL	activates	gene	0.60
MTOR	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPP1CA in their description or question text

No additional research found