Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PCBP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | PCBP2 |
| Full Name | Poly(rC) Binding Protein 2 |
| Chromosome | 12q13.13 |
| Function | Different KH domain combinations confer substrate specificity and tissue-specific functions. |
| Primary Expression | most neuronal subtypes with particular enrichment in glutamatergic neurons |
| Molecular Weight | 38 kDa |
| Amino Acids | 361 aa |
| UniProt ID | Q15366 |
| NCBI Gene ID | 5096 |
| Ensembl ID | ENSG00000197111 |
| GeneCards | PCBP2 |
| Human Protein Atlas | PCBP2 |
| mRNA stability | PCBP2 binds to AU-rich elements (AREs) and C-rich sequences in mRNA 3'UTRs, regulating mRNA decay rates |
| Translation regulation | PCBP2 can either promote or inhibit translation depending on context and bound sequence |
| Alternative splicing | PCBP2 influences splice site selection in pre-mRNA processing |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | CN-0928 |
| Interactions | ATG5, FTH1, LC3 |
| KG Connections | 21 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PCBP2(["PCBP2"])
style PCBP2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
Biomolecular_Condensates["Biomolecular Condensates"]
CN_0928(["CN-0928"])
BACE1["BACE1"]
Mitochondrial_Function(("Mitochondrial Function"))
INTS1(["INTS1"])
Cognitive_Decline["Cognitive Decline"]
mRNA_Decay(["mRNA Decay"])
neurodegeneration["neurodegeneration"]
PCBP2 -->|"associated_with"| Biomolecular_Condensates
CN_0928 -.->|"inhibits"| PCBP2
PCBP2 -->|"regulates"| BACE1
PCBP2 -.->|"inhibits"| Mitochondrial_Function
INTS1 -->|"regulates"| PCBP2
PCBP2 -->|"contributes_to"| Cognitive_Decline
PCBP2 -->|"mediates"| mRNA_Decay
PCBP2 -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class Biomolecular_Condensates protein
class CN_0928 protein
class BACE1 gene
class Mitochondrial_Function pathway
class INTS1 protein
class Cognitive_Decline disease
class mRNA_Decay protein
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| Biomolecular Condensates | associated_with | process | 0.95 |
| BACE1 | regulates | gene | 0.88 |
| Mitochondrial Function | inhibits | process | 0.85 |
| Cognitive Decline | contributes_to | phenotype | 0.84 |
| mRNA Decay | mediates | process | 0.82 |
| autophagy pathway | participates_in | pathway | 0.60 |
| PEX13 | targets | gene | 0.60 |
| PPP1CA | targets | gene | 0.60 |
| VPS29 | targets | gene | 0.60 |
| VPS35 | targets | gene | 0.60 |
| YBX1 | targets | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PCBP2 in their description or question text
No additional research found