protein 621 words KG: EZH2PROTEIN
Contents

EZH2 Protein

🔬 Protein Info
Gene SymbolEZH2
Full NameEnhancer of Zeste Homolog 2
Chromosome7q36.1
FunctionH3K27me3 is the transcriptionally repressive mark that defines Polycomb-silenced chromatin.
Subcellular Localization** | Nucleus |
Molecular Weight85.4 kDa
Amino Acids746 aa
Exons20
PathwaysAutophagy, Circadian Rhythm, Epigenetic, Histone Modification, Inflammasome
UniProt IDQ15910
NCBI Gene ID2146
Ensembl IDENSG00000106462
OMIM601573
GeneCardsEZH2
Human Protein AtlasEZH2
Associated DiseasesCancer, Infection, Inflammation, major depressive disorder, neurodegeneration, Prostate Cancer
Known Drugs/CompoundsEPZ6438
InteractionsAGING, AKT, AMPK, AND, App, ATG16L1
SciDEX HypothesesEZH2 Inhibitor Therapy to Restore Neuronal Identit
KG Connections291 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

Related Hypotheses (10)

Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.97
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (8)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 4 hypotheses
Synaptic Biomarkers in Neurodegeneration
biomarker · Pages share 4 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 4 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 4 hypotheses

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)