Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MMP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Glycocalyx | degrades | biomarker | 0.95 |
| Hypertrophic Scar | drives | disease | 0.85 |
| ischemic stroke | implicated_in | disease | 0.80 |
| Blood-Brain Barrier Dysfunction | mediates | phenotype | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TNF | activates | protein | 0.90 |
| IL1B | activates | protein | 0.90 |
| exosomes | inhibits | protein | 0.85 |
| ASH1L | inhibits | gene | 0.80 |
| 5-fluorouracil | suppresses | drug | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SASP Secretome-based Molecular Distinction via CXCL1/CXCL2/M | 0.720 | neurodegeneration | How can senescent microglia be molecular |
| SASP-Secreted MMP-9 from Senescent Microglia Generates Patho | 0.682 | ALS | What are the mechanisms by which microgl |
| Dual NF-κB/MMP Inhibition Strategy | 0.554 | - | Blood-brain barrier tight junction disru |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.919
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Resveratrol protection against renal I/R injury in diabetic rats | validation | diabetic nephropathy | 0.900 | 0.00 | streptozotocin-induced diabeti | proposed | N/A |
| Resveratrol effects on HK-2 cells under hypoxia/reoxygenation | exploratory | diabetic nephropathy | 0.850 | 0.00 | HK-2 cells cultured in high gl | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.76 · 2026-04-23
closed · Rounds: 7 · Score: 0.87 · 2026-04-16
Hypotheses and analyses mentioning MMP in their description or question text
No additional research found