gene

HERC3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HERC3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

10Outgoing

4Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	HERC3
Full Name	HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 3
Chromosome	4q22.1
Protein Type	Ligase
Function	encodes a HECT domain E3 ubiquitin ligase that plays critical roles in protein quality control, autophagy, and NF-κB signaling.
Primary Expression	Brain (substantia nigra, cortex), Liver, Lung
Molecular Weight	280 kDa
Amino Acids	528 aa
Pathways	NF-κB signaling
UniProt ID	Q9NPA8
NCBI Gene ID	57524
Ensembl ID	ENSG00000163795
OMIM	609419
GeneCards	HERC3
Human Protein Atlas	HERC3
Associated Diseases	Parkinson's Disease, Alzheimer's Disease
KG Connections	14 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HERC3 — AlphaFold Q9NPA8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HERC3 — HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 3

gene · 2680 words

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Pathway Diagram

graph TD
    HERC3["HERC3"]
    microglia["microglia"]
    HERC3 -->|"associated with"| microglia
    MM1["MM1"]
    HERC3 -->|"ubiquitinates"| MM1
    RPL23A["RPL23A"]
    HERC3 -->|"ubiquitinates"| RPL23A
    cell_proliferation["cell proliferation"]
    HERC3 -->|"regulates"| cell_proliferation
    cell_cycle["cell cycle"]
    HERC3 -->|"regulates"| cell_cycle
    neurodegeneration["neurodegeneration"]
    HERC3 -->|"implicated in"| neurodegeneration
    _Np63_["DeltaNp63alpha"]
    _Np63_ -->|"upregulates"| HERC3
    style HERC3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
microglia	associated_with	cell_type	0.80
cell proliferation	regulates	process	0.80
cell cycle	regulates	process	0.80
MM1	ubiquitinates	protein	0.80
RPL23A	ubiquitinates	protein	0.80
Als	contributes_to	disease	0.65
Immune Response	contributes_to	pathway	0.60
T Cell	contributes_to	cell_type	0.60
Ubiquitin	contributes_to	protein	0.60
Proteasome	contributes_to	protein	0.60

Incoming (4)

Source	Relation	Type	Str
ΔNp63α	upregulates	transcription_factor	0.80
HERC5	contributes_to	gene	0.60
HERC6	contributes_to	gene	0.60
UBIQUITIN	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HERC3 in their description or question text

No additional research found