| Gene Symbol | CHECK1 |
| Full Name | Cell Cycle Checkpoint Kinase 1 |
| Aliases | CHK1, Cdc2-like 1 (CLK1) |
| Chromosome | 11q24.2 |
| Protein Type | Kinase |
| Function | Upon genotoxic insult, ATR phosphorylates CHECK1 at multiple sites—most critically at Ser317 and Ser345—triggering a conformational change that enables kinase activity[@global2023]. |
| Primary Expression | Ubiquitous; highest in brain, testis, thymus |
| Molecular Weight | 54 kDa |
| Amino Acids | 433 aa |
| UniProt ID | O14757 |
| NCBI Gene ID | 1111 |
| GeneCards | CHECK1 |
| Human Protein Atlas | CHECK1 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, Huntington's disease, ALS |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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