gene

CCL4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCL4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

175Connections

0Hypotheses

0Analyses

50Outgoing

47Incoming

0Experiments

0Debates

Summary

CCL4 (C-C motif chemokine ligand 4), also known as MIP-1β, is a CC chemokine that plays critical roles in neuroinflammation, microglial activation, and neurodegenerative processes in Alzheimer's disease, Parkinson's disease, and multiple sclerosis.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	CCL4
Full Name	C-C motif chemokine ligand 4
Chromosome	17q12
Function	is a member of the CC chemokine family that plays critical roles in immune cell recruitment and neuroinflammation.
Molecular Weight	10 kDa
Amino Acids	92 aa
Exons	3
Pathways	PI3K, MAPK, NF-κB pathway
NCBI Gene ID	6351
Ensembl ID	ENSG00000129277
GeneCards	CCL4
Human Protein Atlas	CCL4
Associated Diseases	Aging, Als, Cancer, Fibrosis, Inflammation
Interactions	AKT, Albumin, AND, App, AUTOPHAGY, CCL2
KG Connections	174 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CCL4 Gene

gene · 1267 words

→

CCL4 Protein

protein · 591 words

→

Pathway Diagram

flowchart TD
    CCL4["CCL4"] -->|"activates"| CCR5["CCR5"]
    CCL4["CCL4"] -->|"activates"| Inflammation["Inflammation"]
    CCL4["CCL4"] -->|"activates"| Ms["Ms"]
    CCL4["CCL4"] -->|"activates"| Fibrosis["Fibrosis"]
    CCL4["CCL4"] -->|"activates"| Huntington["Huntington"]
    CCL4["CCL4"] -->|"activates"| Tauopathy["Tauopathy"]
    CCL4["CCL4"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    CCL4["CCL4"] -->|"associated with"| Fibrosis["Fibrosis"]
    CCL4["CCL4"] -->|"associated with"| Ms["Ms"]
    CCL4["CCL4"] -->|"associated with"| Inflammation["Inflammation"]
    CCL4["CCL4"] -->|"activates"| Autoimmune["Autoimmune"]
    CCL4["CCL4"] -->|"activates"| Als["Als"]
    style CCL4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style CCR5 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Huntington fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tauopathy fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style Autoimmune fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (128)

Target	Relation	Type	Str
CCR5	activates	gene	0.90
hepatic fibrosis	causes	disease	0.90
Tumor	activates	disease	0.75
T cells	expressed_in	cell_type	0.70
Mtor	activates	pathway	0.70
Autophagy	activates	pathway	0.70
PI3K	activates	gene	0.70
Als	activates	disease	0.65
Cirrhosis	interacts_with	disease	0.65
Tauopathy	activates	disease	0.65
Inflammation	activates	disease	0.65
Fibrosis	interacts_with	disease	0.65
Inflammation	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Tumor	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Als	biomarker_for	disease	0.65
Autoimmune	activates	disease	0.65
Aging	associated_with	disease	0.65
Carcinoma	interacts_with	disease	0.65
Ms	activates	disease	0.65
Fibrosis	activates	disease	0.65
Inflammation	biomarker_for	disease	0.65
Fibrosis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Huntington	activates	disease	0.65
Ms	associated_with	disease	0.65
Ferroptosis	activates	disease	0.65
IL7	associated_with	gene	0.60
C1QB	associated_with	gene	0.60
FOXO1	activates	gene	0.60
GPX4	interacts_with	gene	0.60
C1QA	associated_with	gene	0.60
CCL5	activates	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
FUNDC1	activates	gene	0.60
FOXO1	regulates	entity	0.60
AKT	activates	gene	0.60
STAT1	activates	gene	0.60
Akt	activates	pathway	0.60
HSPA1A	activates	gene	0.60
CCL3	activates	gene	0.60
TGF	activates	gene	0.60
Pi3K	activates	pathway	0.60
STAT3	activates	gene	0.60
TNF	activates	gene	0.60
Tgf-Β	activates	pathway	0.60
CD4	regulates	gene	0.60
TLR4	activates	gene	0.60

Incoming (47)

Source	Relation	Type	Str
PI3K	activates	gene	0.60
AKT	activates	gene	0.60
CCL5	activates	gene	0.60
CCL3	activates	gene	0.60
CCR5	activates	gene	0.60
MTOR	activates	gene	0.60
LC3	therapeutic_target	gene	0.60
GPX4	interacts_with	gene	0.60
C1QB	associated_with	gene	0.60
CCL5	associated_with	gene	0.60
MICROGLIA	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
LC3	phosphorylates	gene	0.60
C1QA	associated_with	gene	0.60
TAUOPATHY	activates	gene	0.60
FOXO1	activates	gene	0.60
MTORC1	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
ROS	interacts_with	gene	0.60
CCL2	associated_with	gene	0.60
CCL2	expressed_in	gene	0.60
CXCL8	associated_with	gene	0.60
STAT3	activates	gene	0.60
STAT1	activates	gene	0.60
GENES	associated_with	gene	0.60
CCL2	activates	gene	0.60
CXCL10	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
JAK	activates	gene	0.60
AND	activates	gene	0.60
MAPK	activates	gene	0.60
NF-ΚB	activates	gene	0.60
TLR	activates	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
FERROPTOSIS	activates	gene	0.60
FUNDC1	activates	gene	0.50
FUNDC1	associated_with	gene	0.50
Autophagy	activates	process	0.50
mTOR	activates	entity	0.50
mTOR	associated_with	entity	0.50
C1QA	co_expressed_with	gene	0.50
C1QB	co_expressed_with	gene	0.50
FOXO1	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CCL4 in their description or question text

No additional research found