gene

HNRNPH1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HNRNPH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

0Analyses

15Outgoing

15Incoming

0Experiments

0Debates

Summary

HNRNPH1 gene - RNA processing in ALS/AD - heterogeneous nuclear ribonucleoprotein H1 involved in alternative splicing, stress granules, and neurodegeneration

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🧬 Gene Info

Gene Symbol	HNRNPH1
Full Name	Heterogeneous Nuclear Ribonucleoprotein H1
Aliases	HNRNPH1 gene
Chromosome	5q31.3
Function	RNA processing, alternative splicing, stress granule formation
Primary Expression	both neurons and glial cells
Subcellular Localization	Nucleus: Primary localization; concentrated in splicing speckles
Amino Acids	449 aa
Exons	10
Pathways	Apoptosis, Autophagy, Innate Immunity
UniProt ID	P31946
NCBI Gene ID	3067
Ensembl ID	ENSG00000135638
GeneCards	HNRNPH1
Human Protein Atlas	HNRNPH1
Associated Diseases	neurodegeneration
Interactions	AND, APOPTOSIS, AUTOPHAGY, BRCA1, BRCA2, CANCER
KG Connections	30 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HNRNPH1 — AlphaFold P31946 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HNRNPH1 Gene

gene · 1198 words

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Pathway Diagram

graph TD
    HNRNPH1["HNRNPH1"]
    Aging{"Aging"}
    HNRNPH1 -->|"regulates"| Aging
    Neurodegeneration{"Neurodegeneration"}
    HNRNPH1 -->|"regulates"| Neurodegeneration
    Als{"Als"}
    HNRNPH1 -->|"regulates"| Als
    Cancer{"Cancer"}
    HNRNPH1 -->|"regulates"| Cancer
    Longevity{"Longevity"}
    HNRNPH1 -->|"regulates"| Longevity
    Ms{"Ms"}
    HNRNPH1 -->|"regulates"| Ms
    Tumor{"Tumor"}
    HNRNPH1 -->|"activates"| Tumor
    HNRNPH1 -->|"activates"| Ms
    HNRNPH1 -->|"activates"| Cancer
    BRCA2["BRCA2"]
    HNRNPH1 -->|"activates"| BRCA2
    Innate_Immunity(["Innate Immunity"])
    HNRNPH1 -->|"activates"| Innate_Immunity
    APOPTOSIS["APOPTOSIS"]
    HNRNPH1 -->|"activates"| APOPTOSIS
    AGING["AGING"]
    AGING -->|"regulates"| HNRNPH1
    SIRT6["SIRT6"]
    SIRT6 -->|"regulates"| HNRNPH1
    PARP1["PARP1"]
    PARP1 -->|"activates"| HNRNPH1
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"regulates"| HNRNPH1
    HNRNPA1["HNRNPA1"]
    HNRNPA1 -->|"activates"| HNRNPH1
    P53["P53"]
    P53 -->|"activates"| HNRNPH1
    MYC["MYC"]
    MYC -->|"regulates"| HNRNPH1
    DDX5["DDX5"]
    DDX5 -->|"activates"| HNRNPH1
    PIN1["PIN1"]
    PIN1 -->|"regulates"| HNRNPH1
    CANCER["CANCER"]
    CANCER -->|"regulates"| HNRNPH1
    BRCA1["BRCA1"]
    BRCA1 -->|"activates"| HNRNPH1
    ATR["ATR"]
    ATR -->|"regulates"| HNRNPH1
    style HNRNPH1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (15)

Target	Relation	Type	Str
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Longevity	regulates	disease	0.65
Ms	regulates	disease	0.65
Tumor	activates	disease	0.65
Aging	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Apoptosis	activates	pathway	0.60
Autophagy	activates	pathway	0.60
AUTOPHAGY	activates	gene	0.60
Innate Immunity	activates	pathway	0.60
APOPTOSIS	activates	gene	0.60
BRCA2	activates	gene	0.60

Incoming (15)

Source	Relation	Type	Str
CANCER	regulates	gene	0.60
CANCER	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AND	activates	gene	0.60
SIRT6	regulates	gene	0.60
PARP1	activates	gene	0.60
HNRNPA1	activates	gene	0.60
MYC	regulates	gene	0.60
DDX5	activates	gene	0.60
PIN1	regulates	gene	0.60
BRCA1	activates	gene	0.60
ATR	regulates	gene	0.60
AGING	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
P53	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HNRNPH1 in their description or question text

No additional research found