gene 654 words KG: BRCA2
Contents

BRCA2 Gene

🧬 Gene Info
Gene SymbolBRCA2
Full NameBRCA2 DNA Repair Associated
Chromosome13q13.1
FunctionThe BRCA2 gene encodes BRCA2 DNA Repair Associated, involved in DNA repair and genomic stability
Molecular Weight384 kDa
PathwaysAutophagy, Ferroptosis, Homologous Recombination, Innate Immunity, Oxidative Stress
UniProt IDBRCA2
NCBI Gene ID675
Ensembl IDENSG00000139618
OMIM600185
GeneCardsBRCA2
Human Protein AtlasBRCA2
DNA repairCritical for maintaining genomic integrity
Cell cycle regulationCoordinates DNA repair with cell cycle progression
[Apoptosis](/entities/apoptosis)Modulates apoptotic response to DNA damage
Associated DiseasesAls, Breast Cancer, Cancer, Carcinoma
InteractionsAPOPTOSIS, ATM, AUTOPHAGY, BRCA1, CANCER, CDKN2A
KG Connections160 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

PARP1 Inhibition Therapy
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Apoptosis in Neurodegeneration
entity · KG edge: inhibits
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ATM Gene
gene · KG edge: associated_with
ATR Gene
gene · KG edge: regulates
BICD2 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CD38 therapeutic_target BRCA2
FOXP1 therapeutic_target BRCA2
TERT therapeutic_target BRCA2
LC3 activates BRCA2
P62 activates BRCA2
TRIM25 activates BRCA2
SIRT6 regulates BRCA2
PARP1 regulates BRCA2
HNRNPA1 activates BRCA2
MYC regulates BRCA2

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