gene 1,970 words KG: ABIN1
Contents

ABIN1 (TNIP1) Gene

🧬 Gene Info
Gene SymbolABIN1
Full NameTNFAIP3 Interacting Protein 1
Chromosome5q33.1
Functionencodes a ubiquitin-binding protein that serves as a critical negative regulator of nuclear factor kappa B (NF-κB) signaling.
Molecular Weight79 kDa
Amino Acids647 aa
Exons13
PathwaysNF-κB, NF-κB signaling
UniProt IDQ9Y5J7
NCBI Gene ID10672
Ensembl IDENSG00000134250
OMIM607416
GeneCardsABIN1
Human Protein AtlasABIN1
Associated Diseasesdepression
InteractionsNFKB, NF-ΚB
KG Connections15 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (8)

CYP46A1 Overexpression Gene Therapy
Score: 0.95
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.54

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Ubiquitin-Proteasome System Therapeutic Companies for P
company · KG edge: regulates
Neurodegeneration
disease · KG edge: implicated_in
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
PI3K — Phosphoinositide 3-Kinase
gene · KG edge: regulates
TOLLIP — Toll-Interacting Protein
gene · KG edge: regulates

Knowledge Graph (12 edges)

TOLLIP regulates ABIN1
UBIQUITIN regulates ABIN1
ABIN1 regulates PI3K
ABIN1 regulates AKT
ABIN1 associated_with depression
genes-abin1 describes ABIN1
NFKB inhibits ABIN1
ABIN1 regulates INFLAMMATION
ABIN1 inhibits NF-ΚB
ABIN1 regulates AUTOPHAGY

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