gene 3,043 words KG: BIN1
Contents

BIN1 — Bridging Integrator 1

🧬 Gene Info
Gene SymbolBIN1
Full NameBridging Integrator 1
Chromosome2q14.3
Functionis a gene located on chromosome 2q14.
Primary ExpressionCerebral cortex, Hippocampus, White matter, Cerebellum
Molecular Weight70 kDa
Exons20
PathwaysAutophagy, Complement, Endocytosis, proinflammatory activation
UniProt IDO00499
NCBI Gene ID274
Ensembl IDENSG00000136717
OMIM601248
GeneCardsBIN1
Human Protein AtlasBIN1
Associated Diseasesaging, Als, Alzheimer, Alzheimer disease
InteractionsABCA7, Actin, AD, ADAM10, ADAMTS4, AGING
KG Connections1000 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (23)

Optogenetic Control of Mitochondrial Transfer Networks
Score: 0.48
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Phase-Separated Organelle Targeting
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
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Related Analyses (7)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

See Also (6)

ABCA7 (Redirect)
redirect · KG edge: activates
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with
adam17
gene · KG edge: associated_with

Knowledge Graph (12 edges)

BIN1 regulates phosphorylated tau
CD8 expressed_in BIN1
STAT1 activates BIN1
BIN1 activates G3BP1
EPAS1 associated_with BIN1
CACNG6 associated_with BIN1
BIN1 therapeutic_target CHRNA2
BIN1 associated_with CEBPA
BIN1 therapeutic_target CNR1
BIN1 associated_with CTSD

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