concept

AHR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AHR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

458Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

1Experiments

1Debates

Summary

AHR is a concept in neurodegeneration research. Key relationships include: inhibits, activates, associated with. Associated with ALS, Aging, Als. Connected to 274 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	AHR
Key Genes/Proteins	AADC, Actin, AGING, AKT, ALDH, ALZHEIMER
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Adaptive Immunity, Amyloid
Linked Hypotheses	1 hypotheses

🧬 3D Structure Comparison — AHR Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

5NJ8 — X-ray / Cryo-EM

🔮 AI Predicted Structure

A0A2R8Y7G1 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    AHR["AHR"]
    AHR -->|"inhibits"| SYNAPTOPHYSINSYP["SYNAPTOPHYSINSYP"]
    AHR -.protects against.-> Alzheimer_s_disease["Alzheimer's disease"]
    AHR -->|"inhibits"| RAGE_NF__B["RAGE/NF-kappaB"]
    AHR -->|"inhibits"| microglia["microglia"]
    AHR -->|"regulates"| Parkinson["Parkinson"]
    AHR -->|"regulates"| Als["Als"]
    AHR -->|"activates"| Inflammation["Inflammation"]
    AHR -->|"inhibits"| Ms["Ms"]
    AHR -->|"activates"| Fibrosis["Fibrosis"]
    h_f9c6fa3f["h-f9c6fa3f"] -->|"targets"| AHR
    Indoles["Indoles"] -->|"activates"| AHR
    indoleacetic_acid["indoleacetic acid"] -->|"activates"| AHR
    BENVITIMOD["BENVITIMOD"] -->|"activates"| AHR
    CLDN1["CLDN1"] -->|"inhibits"| AHR
    NRF2["NRF2"] -->|"inhibits"| AHR
    ARNT["ARNT"] -->|"activates"| AHR
    CTSS["CTSS"] -->|"inhibits"| AHR
    P62["P62"] -->|"activates"| AHR
    CYTOKINES["CYTOKINES"] -->|"inhibits"| AHR

Outgoing (329)

Target	Relation	Type	Str
Inflammation	inhibits	disease	0.95
Als	inhibits	disease	0.95
Inflammation	activates	disease	0.95
Alzheimer's Disease	associated_with	disease	0.90
INFLAMMATION	inhibits	gene	0.90
Aging	regulates	disease	0.85
Retinal Ganglion Cell Apoptosis	inhibits	process	0.85
Retinal Ischemia/Reperfusion Injury	protects_against	disease	0.85
glaucoma	protects_against	disease	0.82
Oxidative Stress	associated_with	process	0.80
ERK	inhibits	protein	0.80
SYNAPTOPHYSINSYP	inhibits	gene	0.80
eNOS	associated_with	enzyme	0.80
Immune Response	regulates	pathway	0.80
Als	activates	disease	0.75
Glaucoma	associated_with	disease	0.75
Cancer	regulates	disease	0.75
Als	regulates	disease	0.75
Als	therapeutic_target	disease	0.75
Tumor	inhibits	disease	0.75
Inflammation	regulates	disease	0.75
IPA	activates	protein	0.70
Alzheimer's disease	protects_against	disease	0.70
RAGE/NF-κB	inhibits	pathway	0.70
Microbiota	inhibits	pathway	0.70
Nf-Κb	regulates	pathway	0.70
microglia	inhibits	cell_type	0.70
Senescence	activates	disease	0.65
Cancer	associated_with	disease	0.65
Ms	activates	disease	0.65
Fibrosis	activates	disease	0.65
Asthma	regulates	disease	0.65
Cardiovascular	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Psoriasis	therapeutic_target	disease	0.65
Infection	regulates	disease	0.65
Stroke	therapeutic_target	disease	0.65
Colorectal Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Als	interacts_with	disease	0.65
Senescence	regulates	disease	0.65
Hypertension	inhibits	disease	0.65
Aging	activates	disease	0.65
Inflammatory Bowel Disease	regulates	disease	0.65
Pneumonia	regulates	disease	0.65
Ms	interacts_with	disease	0.65
Depression	treats	disease	0.65
Als	treats	disease	0.65
Depression	activates	disease	0.65
Obesity	associated_with	disease	0.65

Incoming (129)

Source	Relation	Type	Str
ITE	activates	drug	0.92
Tryptophan Metabolites	activates	compound	0.90
h-f9c6fa3f	targets	hypothesis	0.90
Kynurenine Metabolites	activates	compound	0.85
Indoles	upregulates	chemical	0.80
AGING	regulates	gene	0.70
NF-ΚB	regulates	gene	0.70
CANCER	regulates	gene	0.70
INFLAMMATION	activates	gene	0.70
indoleacetic acid	activates	drug	0.70
Indoles	activates	process	0.70
IPA	activates	gene	0.70
BENVITIMOD	activates	drug	0.64
PER	associated_with	gene	0.60
ROS	inhibits	gene	0.60
DEMENTIA	associated_with	gene	0.60
MICROGLIA	inhibits	gene	0.60
NEURODEGENERATIVE DISORDERS	inhibits	gene	0.60
ALZHEIMER	associated_with	gene	0.60
APOPTOSIS	regulates	gene	0.60
CANCER	associated_with	gene	0.60
TSLP	associated_with	gene	0.60
NF-KB	regulates	gene	0.60
EPO	inhibits	gene	0.60
OXIDATIVE STRESS	contributes_to	gene	0.60
ERK	inhibits	gene	0.60
INFLAMMATION	regulates	gene	0.60
IL-6	activates	gene	0.60
LDL	activates	gene	0.60
DEPRESSION	activates	gene	0.60
WNT	activates	gene	0.60
IL-13	activates	gene	0.60
ALDH	activates	gene	0.60
P62	activates	gene	0.60
MTOR	regulates	gene	0.60
MYC	regulates	gene	0.60
XPA	regulates	gene	0.60
CLOCK	interacts_with	gene	0.60
PDIA3	regulates	gene	0.60
BMAL1	interacts_with	gene	0.60
NLRP3	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
CYTOKINES	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
NEPRILYSIN	activates	gene	0.60
IDO1	activates	gene	0.60
CYTOKINES	inhibits	gene	0.60
LAMP2	inhibits	gene	0.60
STAT6	activates	gene	0.60
OCLN	inhibits	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ	0.683	neuroinflammation	How do B cells mechanistically orchestra
Aryl Hydrocarbon Receptor (AhR) Activation by Microbiome Met	0.591	neuroinflammation	What molecular mechanisms determine whet

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.888

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
IL-10 deficiency and VLC ceramide accumulation in inflammatory bowel d	validation	inflammatory bowel disease	0.900	0.00	IL-10 knockout mice	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning AHR in their description or question text

No additional research found