gene

XPA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about XPA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections
6Hypotheses
0Analyses
18Outgoing
11Incoming
0Experiments
0Debates

Summary

XPA is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with Aging, Als, Ms. Connected to 20 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolXPA
Full NameXPA DNA Repair Endonuclease
Chromosome9q34.3
FunctionXPA encodes a zinc-finger protein essential for nucleotide excision repair (NER).
Molecular Weight32 kDa
Amino Acids297 aa
PathwaysAutophagy, Circadian Rhythm, Mtor, Nf-Κb
UniProt IDP18077
NCBI Gene ID7508
Ensembl IDENSG00000136936
OMIM278700
GeneCardsXPA
Human Protein AtlasXPA
Associated Diseasesneurodegeneration
InteractionsAND, CLOCK, C-MYC, DNA, MYC, PDIA3
KG Connections29 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: XPA — AlphaFold P18077 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

XPA Gene

gene · 1654 words

Pathway Diagram

graph TD
    XPA["XPA"]
    Senescence{"Senescence"}
    XPA -->|"activates"| Senescence
    Aging{"Aging"}
    XPA -->|"regulates"| Aging
    Als{"Als"}
    XPA -->|"activates"| Als
    Ms{"Ms"}
    XPA -->|"regulates"| Ms
    Tumor{"Tumor"}
    XPA -->|"activates"| Tumor
    CLOCK["CLOCK"]
    XPA -->|"activates"| CLOCK
    AUTOPHAGY["AUTOPHAGY"]
    XPA -->|"regulates"| AUTOPHAGY
    PDIA3["PDIA3"]
    XPA -->|"activates"| PDIA3
    BMAL1["BMAL1"]
    XPA -->|"regulates"| BMAL1
    AHR["AHR"]
    XPA -->|"regulates"| AHR
    CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"]
    XPA -->|"regulates"| CIRCADIAN_RHYTHM
    Autophagy(["Autophagy"])
    XPA -->|"regulates"| Autophagy
    AGING["AGING"]
    AGING -->|"regulates"| XPA
    MTOR["MTOR"]
    MTOR -->|"regulates"| XPA
    MYC["MYC"]
    MYC -->|"activates"| XPA
    NF__B["NF-KappaB"]
    NF__B -->|"regulates"| XPA
    style XPA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (18)

TargetRelationTypeStr
Tumoractivatesdisease0.65
Senescenceactivatesdisease0.65
Agingregulatesdisease0.65
Alsactivatesdisease0.65
Msregulatesdisease0.65

Incoming (11)

SourceRelationTypeStr
AHRregulatesgene0.60
BMAL1regulatesgene0.60
CLOCKactivatesgene0.60
ANDactivatesgene0.60
C-MYCactivatesgene0.60

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion 0.808 neurodegeneration TREM2 agonism vs antagonism in DAM micro
Sleep-Dependent Glymphatic Clearance Expands the Therapeutic 0.780 neurodegeneration What is the therapeutic window between t
Ataxin-2 Polyglutamine Expansions Hijack G3BP1 to Form Toxic 0.700 neurodegeneration How do disease-associated mutations in G
Axonal Transport Defect: C9orf72 hexanucleotide expansion im 0.660 neurodegeneration What are the neuron-specific effects of
Labile iron pool expansion amplifies genotype-specific ALS f 0.639 neurodegeneration Ferroptosis in ALS motor neuron vulnerab
C1Q-Mediated Defective Efferocytosis Driving Necrotic Core E 0.600 neuroinflammation What are the specific molecular mechanis

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] ["Chen Kai", "Li Fuyao", "Zhang Shuwen", Journal of neuroinflammation 2025 0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] ["Chen Kai", "Li Fuyao", "Zhang Shuwen", Journal of neuroinflammation 2025 0
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] Marogianni C, Sokratous M, Dardiotis E, International journal of molec 2020 0
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] Marogianni C, Sokratous M, Dardiotis E, International journal of molec 2020 0
Multiple Sclerosis Pathology. [PMID:29358320] Lassmann H Cold Spring Harbor perspective 2018 0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning XPA in their description or question text

C1Q-Mediated Defective Efferocytosis Driving Necrotic Core Expansion

Score: 0.600 · neuroinflammation · 2026-04-21

## Mechanistic Overview C1Q-Mediated Defective Efferocytosis Driving Necrotic Core Expansion starts from the claim that