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gene 887 words KG: ent-gene-f4701bda
Contents

ATM Gene

🧬 Gene Info
Gene SymbolATM
Full NameAtaxia-Telangiectasia Mutated
Chromosome11q22.3
Protein TypeSerine/Threonine Kinase
Functionis a PIKK-family serine/threonine kinase that coordinates genomic stress responses, especially after DNA double-strand breaks.
PathwaysAkt, Apoptosis, Autophagy, Cell Cycle, Dna Damage Response
UniProt ID[Q13315](https://www.uniprot.org/uniprotkb/Q13315)
Ensembl IDENSG00000149311
GeneCardsATM
Human Protein AtlasATM
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/CompoundsmtDNA, rapamycin
InteractionsABCD3, ACETYL-COA, Actin, AGING, AKT, ALOX
KG Connections1359 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (22)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73R-Loop Resolution Enhancement Therapy
Score: 0.68Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78Aquaporin-4 Polarization Rescue
Score: 0.73CYP46A1 Overexpression Gene Therapy
Score: 0.73Phase-Separated Organelle Targeting
Score: 0.73TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72Stress Granule Phase Separation Modulators
Score: 0.72Mitochondrial Transfer Pathway Enhancement
Score: 0.70Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69RNA Granule Nucleation Site Modulation
Score: 0.66KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65VCP-Mediated Autophagy Enhancement
Score: 0.59Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55
pg 1/2Next →

Related Analyses (10)

Epigenetic reprogramming in aging neurons
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedSenolytic therapy for age-related neurodegeneration
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (15)

Packard Center for ALS Research
institution · KG edge: activatesAIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: contributes_toALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: activatesAccelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_inAging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates

Knowledge Graph (6 edges)

h-ff5951ff09 targets ent-gene-f4701bda
ent-gene-f4701bda targeted_by h-ff5951ff09
h-a3a9b0941b targets ent-gene-f4701bda
ent-gene-f4701bda targeted_by h-a3a9b0941b
ent-gene-f4701bda data_in benchmark_ot_ad_answer_key:ATM
benchmark_ot_ad_answer_key:ATM data_in ent-gene-f4701bda

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